DegronMD

Uniprot ID: Q6UXI9

Source protein: Nephronectin

Source gene: NPNT

Class: DEG_ODPH_VHL_1

Location: 357:370

E3 ligase: VHL

DEGRON score: 0.8206

ASA_SCORE: 58.8286

COIL: 0.665

CONS_SCORE: 0.5498

DSS_SCORE: 0.7238

HELIX: 0.0449

FCONS_SCORE: 0.8641

RIG_SCORE: 0.6482

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P373T	TCGA-B0-4706	KIRC	TCGA	IAPAASTPPGGITV	DEG_ODPH_VHL_1	0.25
p.T349A	TCGA-CG-5728	STAD	TCGA	IAPAASTPPGGITV	DEG_ODPH_VHL_1	0.1111
p.P356S	TCGA-EE-A29Q	SKCM	TCGA	IAPAASTPPGGITV	DEG_ODPH_VHL_1	0.3056
p.P356S	TCGA-ER-A3PL	SKCM	TCGA	IAPAASTPPGGITV	DEG_ODPH_VHL_1	0.3056
p.E378K	TCGA-FR-A726	SKCM	TCGA	IAPAASTPPGGITV	DEG_ODPH_VHL_1	0.1111
p.P359L	TCGA-FS-A1ZK	SKCM	TCGA	IAPAASTPPGGITV	DEG_ODPH_VHL_1	0.7582
p.R379K	TCGA-RP-A695	SKCM	TCGA	IAPAASTPPGGITV	DEG_ODPH_VHL_1	0.0833
p.G353R	DO1285	BRCA	ICGC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	0.2222
p.G353R	MEL-JUSO	skin	COSMIC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	0.2222
p.V374L	DO229045	LICA	ICGC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	0.2222
p.Q379H	DO23732	LUAD	ICGC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	0.0833
p.S362T	DO23557	LUAD	ICGC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	0.6005
p.G353E	DO222662	MELA	ICGC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	0.2222
p.E348K	DO48665	SKCM	ICGC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	0.0833
p.G367W	DO37961	SKCM	ICGC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	0.6714
p.R349K	DO51270	SKCM	ICGC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	0.1111
p.T366K	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	0.7306
p.T366K	ACH-000916	Lung Cancer	CCLE	IAPAASTPPGGITV	DEG_ODPH_VHL_1	0.7306
p.T366K	NCI-H1573	lung	COSMIC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	0.7306
p.K351N	SIDM01519	Head and Neck Carcinoma	GDSC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	0.1667
p.P350A	ACH-001396	Metastasis	CCLE	IAPAASTPPGGITV	DEG_ODPH_VHL_1	0.1389
p.T353K	NCI-H1573	lung	COSMIC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	0.2222
p.L364M	RXF393	kidney	COSMIC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	0.711
p.L351M	RXF393	kidney	COSMIC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	0.1667
p.T355A	NCI-H1792	lung	COSMIC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	0.2778
p.P365Q	COLO-741	large_intestine	COSMIC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	0.5924
p.G370R	MEL-JUSO	skin	COSMIC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	0.7568
p.T372A	NCI-H1792	lung	COSMIC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IAPAASTPPGGITV

Degron related mutations and impact score

Drug responses associated with NPNT mutations

All proteins holding degron of IAPAASTPPGGITV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UXI9	Nephronectin	DEG_ODPH_VHL_1	357:370	IAPAASTPPGGITV	VHL	0.8206	More...