DegronMD - Q6UYE1(DLEU7)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R107H	TCGA-B5-A3FC	UCEC	TCGA	MRSALARVV	DEG_APCC_DBOX_1	117:125	Mutation rewiring degron network	0.0556
p.R107H	DO41871	UCEC	ICGC	MRSALARVV	DEG_APCC_DBOX_1	117:125	Mutation rewiring degron network	0.0556
p.A120T	TCGA-BR-8678	STAD	TCGA	MRSALARVV	DEG_APCC_DBOX_1	117:125	Mutation altering degron motif	0.6028
p.A120T	TCGA-VQ-AA6I	STAD	TCGA	MRSALARVV	DEG_APCC_DBOX_1	117:125	Mutation altering degron motif	0.6028
p.A120T	DO47957	STAD	ICGC	MRSALARVV	DEG_APCC_DBOX_1	117:125	Mutation altering degron motif	0.6028
p.A120T	DO222398	STAD	ICGC	MRSALARVV	DEG_APCC_DBOX_1	117:125	Mutation altering degron motif	0.6028
p.A116V	TCGA-DM-A1HB	COAD	TCGA	MRSALARVV	DEG_APCC_DBOX_1	117:125	Mutation rewiring degron network	0.3056
p.A116V	SIDM02041	Colorectal Carcinoma	GDSC	MRSALARVV	DEG_APCC_DBOX_1	117:125	Mutation rewiring degron network	0.3056
p.S129L	TCGA-EE-A2M5	SKCM	TCGA	MRSALARVV	DEG_APCC_DBOX_1	117:125	Mutation blocking phosphorylation signal	0.6667
p.S129L	TCGA-EY-A1G8	UCEC	TCGA	MRSALARVV	DEG_APCC_DBOX_1	117:125	Mutation blocking phosphorylation signal	0.6667
p.S129L	DO37425	SKCM	ICGC	MRSALARVV	DEG_APCC_DBOX_1	117:125	Mutation blocking phosphorylation signal	0.6667
p.S129L	DO43578	UCEC	ICGC	MRSALARVV	DEG_APCC_DBOX_1	117:125	Mutation blocking phosphorylation signal	0.6667
p.S129L	SIDM00148	Breast Carcinoma	GDSC	MRSALARVV	DEG_APCC_DBOX_1	117:125	Mutation blocking phosphorylation signal	0.6667
p.S129L	ACH-000019	Breast Cancer	CCLE	MRSALARVV	DEG_APCC_DBOX_1	117:125	Mutation blocking phosphorylation signal	0.6667
p.S129L	ACH-000028	Breast Cancer	CCLE	MRSALARVV	DEG_APCC_DBOX_1	117:125	Mutation blocking phosphorylation signal	0.6667
p.S129L	MCF7	breast	COSMIC	MRSALARVV	DEG_APCC_DBOX_1	117:125	Mutation blocking phosphorylation signal	0.6667
p.P109L	TCGA-W3-AA1Q	SKCM	TCGA	MRSALARVV	DEG_APCC_DBOX_1	117:125	Mutation rewiring degron network	0.1111
p.P109L	DO219487	SKCM	ICGC	MRSALARVV	DEG_APCC_DBOX_1	117:125	Mutation rewiring degron network	0.1111
p.S119R	DO229015	LICA	ICGC	MRSALARVV	DEG_APCC_DBOX_1	117:125	Mutation altering degron motif	0.7427
p.S119R	DO229009	LICA	ICGC	MRSALARVV	DEG_APCC_DBOX_1	117:125	Mutation altering degron motif	0.7427
p.R107S	DO52361	LUSC	ICGC	MRSALARVV	DEG_APCC_DBOX_1	117:125	Mutation rewiring degron network	0.0556
p.S133N	DO229272	THCA	ICGC	MRSALARVV	DEG_APCC_DBOX_1	117:125	Mutation rewiring degron network	0.1111
p.M115T	SIDM01004	Chronic Myelogenous Leukemia	GDSC	MRSALARVV	DEG_APCC_DBOX_1	117:125	Mutation rewiring degron network	0.2778
p.M115T	ACH-000983	Leukemia	CCLE	MRSALARVV	DEG_APCC_DBOX_1	117:125	Mutation rewiring degron network	0.2778
p.M115T	KCL-22	haematopoietic and lymphoid tissue	COSMIC	MRSALARVV	DEG_APCC_DBOX_1	117:125	Mutation rewiring degron network	0.2778
p.C110Y	SIDM01617	Endometrial Carcinoma	GDSC	MRSALARVV	DEG_APCC_DBOX_1	117:125	Mutation rewiring degron network	0.1389
p.C110Y	ACH-000994	Endometrial/Uterine Cancer	CCLE	MRSALARVV	DEG_APCC_DBOX_1	117:125	Mutation rewiring degron network	0.1389
p.L112M	ACH-000870	Lung Cancer	CCLE	MRSALARVV	DEG_APCC_DBOX_1	117:125	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DLEU7

UniProt ID: Q6UYE1

Entrez ID: 220107

Protein name: Leukemia-associated protein 7 (Deleted in lymphocytic leukemia 7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DLEU7 in