DegronMD

Uniprot ID: Q6UYE1

Source protein: Leukemia-associated protein 7

Source gene: DLEU7

Class: DEG_APCC_DBOX_1

Location: 117:125

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5801

ASA_SCORE: 59.2667

COIL: 0.1883

CONS_SCORE: 0.6202

DSS_SCORE: 0.2508

HELIX: 0.8009

FCONS_SCORE: 0.9941

RIG_SCORE: 0.7883

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R107H	TCGA-B5-A3FC	UCEC	TCGA	MRSALARVV	DEG_APCC_DBOX_1	0.0556
p.R107H	DO41871	UCEC	ICGC	MRSALARVV	DEG_APCC_DBOX_1	0.0556
p.A120T	TCGA-BR-8678	STAD	TCGA	MRSALARVV	DEG_APCC_DBOX_1	0.6028
p.A120T	TCGA-VQ-AA6I	STAD	TCGA	MRSALARVV	DEG_APCC_DBOX_1	0.6028
p.A120T	DO47957	STAD	ICGC	MRSALARVV	DEG_APCC_DBOX_1	0.6028
p.A120T	DO222398	STAD	ICGC	MRSALARVV	DEG_APCC_DBOX_1	0.6028
p.A116V	TCGA-DM-A1HB	COAD	TCGA	MRSALARVV	DEG_APCC_DBOX_1	0.3056
p.A116V	SIDM02041	Colorectal Carcinoma	GDSC	MRSALARVV	DEG_APCC_DBOX_1	0.3056
p.S129L	TCGA-EE-A2M5	SKCM	TCGA	MRSALARVV	DEG_APCC_DBOX_1	0.6667
p.S129L	TCGA-EY-A1G8	UCEC	TCGA	MRSALARVV	DEG_APCC_DBOX_1	0.6667
p.S129L	DO37425	SKCM	ICGC	MRSALARVV	DEG_APCC_DBOX_1	0.6667
p.S129L	DO43578	UCEC	ICGC	MRSALARVV	DEG_APCC_DBOX_1	0.6667
p.S129L	SIDM00148	Breast Carcinoma	GDSC	MRSALARVV	DEG_APCC_DBOX_1	0.6667
p.S129L	ACH-000019	Breast Cancer	CCLE	MRSALARVV	DEG_APCC_DBOX_1	0.6667
p.S129L	ACH-000028	Breast Cancer	CCLE	MRSALARVV	DEG_APCC_DBOX_1	0.6667
p.S129L	MCF7	breast	COSMIC	MRSALARVV	DEG_APCC_DBOX_1	0.6667
p.P109L	TCGA-W3-AA1Q	SKCM	TCGA	MRSALARVV	DEG_APCC_DBOX_1	0.1111
p.P109L	DO219487	SKCM	ICGC	MRSALARVV	DEG_APCC_DBOX_1	0.1111
p.S119R	DO229015	LICA	ICGC	MRSALARVV	DEG_APCC_DBOX_1	0.7427
p.S119R	DO229009	LICA	ICGC	MRSALARVV	DEG_APCC_DBOX_1	0.7427
p.R107S	DO52361	LUSC	ICGC	MRSALARVV	DEG_APCC_DBOX_1	0.0556
p.S133N	DO229272	THCA	ICGC	MRSALARVV	DEG_APCC_DBOX_1	0.1111
p.M115T	SIDM01004	Chronic Myelogenous Leukemia	GDSC	MRSALARVV	DEG_APCC_DBOX_1	0.2778
p.M115T	ACH-000983	Leukemia	CCLE	MRSALARVV	DEG_APCC_DBOX_1	0.2778
p.M115T	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	MRSALARVV	DEG_APCC_DBOX_1	0.2778
p.C110Y	SIDM01617	Endometrial Carcinoma	GDSC	MRSALARVV	DEG_APCC_DBOX_1	0.1389
p.C110Y	ACH-000994	Endometrial/Uterine Cancer	CCLE	MRSALARVV	DEG_APCC_DBOX_1	0.1389
p.L112M	ACH-000870	Lung Cancer	CCLE	MRSALARVV	DEG_APCC_DBOX_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MRSALARVV

Degron related mutations and impact score

Drug responses associated with DLEU7 mutations

All proteins holding degron of MRSALARVV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UYE1	Leukemia-associated protein 7	DEG_APCC_DBOX_1	117:125	MRSALARVV	APC,CDC20,FZR1	0.5801	More...