DegronMD - Q6WRX3(ZYG11A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M757I	TCGA-A5-A0G1	UCEC	TCGA	QRPTLCQMP	DEG_APCC_DBOX_1	750:758	Mutation altering degron motif	0.6507
p.M757I	DO42472	UCEC	ICGC	QRPTLCQMP	DEG_APCC_DBOX_1	750:758	Mutation altering degron motif	0.6507
p.P758S	TCGA-A5-A0G1	UCEC	TCGA	QRPTLCQMP	DEG_APCC_DBOX_1	750:758	Mutation altering degron motif	0.5641
p.P758S	DO42472	UCEC	ICGC	QRPTLCQMP	DEG_APCC_DBOX_1	750:758	Mutation altering degron motif	0.5641
p.M744I	DO229026	LICA	ICGC	QRPTLCQMP	DEG_APCC_DBOX_1	750:758	Mutation rewiring degron network	0.1667
p.R751S	DO27889	ORCA	ICGC	QRPTLCQMP	DEG_APCC_DBOX_1	750:758	Mutation altering degron motif	0.7427
p.Q750R	SIDM00057	Neuroblastoma	GDSC	QRPTLCQMP	DEG_APCC_DBOX_1	750:758	Mutation altering degron motif	0.6218
p.Q750R	SIDM00552	Rhabdomyosarcoma	GDSC	QRPTLCQMP	DEG_APCC_DBOX_1	750:758	Mutation altering degron motif	0.6218
p.Q750R	ACH-000607	Rhabdoid	CCLE	QRPTLCQMP	DEG_APCC_DBOX_1	750:758	Mutation altering degron motif	0.6218
p.Q750R	KYM-1	soft tissue	COSMIC	QRPTLCQMP	DEG_APCC_DBOX_1	750:758	Mutation altering degron motif	0.6218
p.M747I	SIDM00694	Other Solid Cancers	GDSC	QRPTLCQMP	DEG_APCC_DBOX_1	750:758	Mutation rewiring degron network	0.25
p.D741G	SIDM00683	Prostate Carcinoma	GDSC	QRPTLCQMP	DEG_APCC_DBOX_1	750:758	Mutation rewiring degron network	0.0833
p.D741G	ACH-000977	lymph node	CCLE	QRPTLCQMP	DEG_APCC_DBOX_1	750:758	Mutation rewiring degron network	0.0833
p.D741G	LNCaP-Clone-FGC	prostate	COSMIC	QRPTLCQMP	DEG_APCC_DBOX_1	750:758	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons