DegronMD

Uniprot ID: Q6WRX3

Source protein: Protein zyg-11 homolog A

Source gene: ZYG11A

Class: DEG_APCC_DBOX_1

Location: 750:758

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7854

ASA_SCORE: 102.0444

COIL: 0.9268

CONS_SCORE: 0.2604

DSS_SCORE: 0.4711

HELIX: 0.058

FCONS_SCORE: 0.898

RIG_SCORE: 0.8085

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R751S	DO27889	ORCA	ICGC	QRPTLCQMP	DEG_APCC_DBOX_1	0.7427
p.M757I	TCGA-A5-A0G1	UCEC	TCGA	QRPTLCQMP	DEG_APCC_DBOX_1	0.6507
p.M757I	DO42472	UCEC	ICGC	QRPTLCQMP	DEG_APCC_DBOX_1	0.6507
p.Q750R	SIDM00057	Neuroblastoma	GDSC	QRPTLCQMP	DEG_APCC_DBOX_1	0.6218
p.Q750R	SIDM00552	Rhabdomyosarcoma	GDSC	QRPTLCQMP	DEG_APCC_DBOX_1	0.6218
p.Q750R	ACH-000607	Rhabdoid	CCLE	QRPTLCQMP	DEG_APCC_DBOX_1	0.6218
p.Q750R	KYM-1	soft_tissue	COSMIC	QRPTLCQMP	DEG_APCC_DBOX_1	0.6218
p.P758S	TCGA-A5-A0G1	UCEC	TCGA	QRPTLCQMP	DEG_APCC_DBOX_1	0.5641
p.P758S	DO42472	UCEC	ICGC	QRPTLCQMP	DEG_APCC_DBOX_1	0.5641
p.M747I	SIDM00694	Other Solid Cancers	GDSC	QRPTLCQMP	DEG_APCC_DBOX_1	0.25
p.M744I	DO229026	LICA	ICGC	QRPTLCQMP	DEG_APCC_DBOX_1	0.1667
p.D741G	SIDM00683	Prostate Carcinoma	GDSC	QRPTLCQMP	DEG_APCC_DBOX_1	0.0833
p.D741G	ACH-000977	lymph_node	CCLE	QRPTLCQMP	DEG_APCC_DBOX_1	0.0833
p.D741G	LNCaP-Clone-FGC	prostate	COSMIC	QRPTLCQMP	DEG_APCC_DBOX_1	0.0833

Showing 1 to 14 of 14 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6WRX3	Protein zyg-11 homolog A	DEG_APCC_DBOX_1	750:758	QRPTLCQMP	APC,CDC20,FZR1	0.7854	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons