DegronMD - Q6ZMC9(SIGLEC15)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H293P	TCGA-3N-A9WC	SKCM	TCGA	PDTPPRS	DEG_SCF_FBW7_1	297:303	Mutation rewiring degron network	0.2222
p.P301Q	TCGA-69-7980	LUAD	TCGA	PDTPPRS	DEG_SCF_FBW7_1	297:303	Mutation altering degron motif	0.5924
p.E311D	TCGA-A5-A2K5	UCEC	TCGA	PDTPPRS	DEG_SCF_FBW7_1	297:303	Mutation rewiring degron network	0.1111
p.Q306H	TCGA-AJ-A5DW	UCEC	TCGA	PDTPPRS	DEG_SCF_FBW7_1	297:303	Mutation rewiring degron network	0.25
p.Q306H	TCGA-DA-A1IB	SKCM	TCGA	PDTPPRS	DEG_SCF_FBW7_1	297:303	Mutation rewiring degron network	0.25
p.L313F	TCGA-BH-A0EI	BRCA	TCGA	PDTPPRS	DEG_SCF_FBW7_1	297:303	Mutation rewiring degron network	0.0556
p.E307K	TCGA-EE-A2GO	SKCM	TCGA	PDTPPRS	DEG_SCF_FBW7_1	297:303	Mutation rewiring degron network	0.2222
p.R290C	ACH-000990	Endometrial/Uterine Cancer	CCLE	PDTPPRS	DEG_SCF_FBW7_1	297:303	Mutation rewiring degron network	0.1389
p.E311V	ACH-001097	Lymphoma	CCLE	PDTPPRS	DEG_SCF_FBW7_1	297:303	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons