DegronMD

Uniprot ID: Q6ZMC9

Source protein: Sialic acid-binding Ig-like lectin 15

Source gene: SIGLEC15

Class: DEG_SCF_FBW7_1

Location: 297:303

E3 ligase: FBXW7

DEGRON score: 0.7828

ASA_SCORE: 105.2286

COIL: 0.9583

CONS_SCORE: 0.3548

DSS_SCORE: 0.8242

HELIX: 0.0291

FCONS_SCORE: 1.0242

RIG_SCORE: 0.5966

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H293P	TCGA-3N-A9WC	SKCM	TCGA	PDTPPRS	DEG_SCF_FBW7_1	0.2222
p.P301Q	TCGA-69-7980	LUAD	TCGA	PDTPPRS	DEG_SCF_FBW7_1	0.5924
p.E311D	TCGA-A5-A2K5	UCEC	TCGA	PDTPPRS	DEG_SCF_FBW7_1	0.1111
p.Q306H	TCGA-AJ-A5DW	UCEC	TCGA	PDTPPRS	DEG_SCF_FBW7_1	0.25
p.Q306H	TCGA-DA-A1IB	SKCM	TCGA	PDTPPRS	DEG_SCF_FBW7_1	0.25
p.L313F	TCGA-BH-A0EI	BRCA	TCGA	PDTPPRS	DEG_SCF_FBW7_1	0.0556
p.E307K	TCGA-EE-A2GO	SKCM	TCGA	PDTPPRS	DEG_SCF_FBW7_1	0.2222
p.R290C	ACH-000990	Endometrial/Uterine Cancer	CCLE	PDTPPRS	DEG_SCF_FBW7_1	0.1389
p.E311V	ACH-001097	Lymphoma	CCLE	PDTPPRS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZMC9	Sialic acid-binding Ig-like lectin 15	DEG_SCF_FBW7_1	297:303	PDTPPRS	FBXW7	0.7828	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons