DegronMD - Q6ZMS7(ZNF783)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H232N	TCGA-43-8118	LUSC	TCGA	LPPYPE	LIG_APCC_ABBA_1	226:231	Mutation rewiring degron network	0.3056
p.H232N	DO45471	LUSC	ICGC	LPPYPE	LIG_APCC_ABBA_1	226:231	Mutation rewiring degron network	0.3056
p.G217R	TCGA-64-1676	LUAD	TCGA	LPPYPE	LIG_APCC_ABBA_1	226:231	Mutation rewiring degron network	0.0833
p.G217R	DO23629	LUAD	ICGC	LPPYPE	LIG_APCC_ABBA_1	226:231	Mutation rewiring degron network	0.0833
p.R220K	TCGA-AB-2868	LAML	TCGA	LPPYPE	LIG_APCC_ABBA_1	226:231	Mutation rewiring degron network	0.1667
p.R220K	DO21595	LAML	ICGC	LPPYPE	LIG_APCC_ABBA_1	226:231	Mutation rewiring degron network	0.1667
p.R218H	TCGA-AX-A06F	UCEC	TCGA	LPPYPE	LIG_APCC_ABBA_1	226:231	Mutation rewiring degron network	0.1111
p.R218H	DO41752	UCEC	ICGC	LPPYPE	LIG_APCC_ABBA_1	226:231	Mutation rewiring degron network	0.1111
p.L233I	TCGA-AX-A3FS	UCEC	TCGA	LPPYPE	LIG_APCC_ABBA_1	226:231	Mutation rewiring degron network	0.2778
p.L233I	DO40879	UCEC	ICGC	LPPYPE	LIG_APCC_ABBA_1	226:231	Mutation rewiring degron network	0.2778
p.L233I	SIDM02021	Esophageal Carcinoma	GDSC	LPPYPE	LIG_APCC_ABBA_1	226:231	Mutation rewiring degron network	0.2778
p.P230Q	TCGA-ER-A196	SKCM	TCGA	LPPYPE	LIG_APCC_ABBA_1	226:231	Mutation altering degron motif	0.5924
p.P230Q	DO47474	SKCM	ICGC	LPPYPE	LIG_APCC_ABBA_1	226:231	Mutation altering degron motif	0.5924
p.P230L	TCGA-FW-A3R5	SKCM	TCGA	LPPYPE	LIG_APCC_ABBA_1	226:231	Mutation altering degron motif	0.6471
p.P230L	DO37406	SKCM	ICGC	LPPYPE	LIG_APCC_ABBA_1	226:231	Mutation altering degron motif	0.6471
p.L233R	DO233663	GACA	ICGC	LPPYPE	LIG_APCC_ABBA_1	226:231	Mutation rewiring degron network	0.2778
p.R218L	DO229045	LICA	ICGC	LPPYPE	LIG_APCC_ABBA_1	226:231	Mutation rewiring degron network	0.1111
p.R218C	SIDM00654	Small Cell Lung Carcinoma	GDSC	LPPYPE	LIG_APCC_ABBA_1	226:231	Mutation rewiring degron network	0.1111
p.R218C	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	LPPYPE	LIG_APCC_ABBA_1	226:231	Mutation rewiring degron network	0.1111
p.R218C	SIDM00907	Burkitt's Lymphoma	GDSC	LPPYPE	LIG_APCC_ABBA_1	226:231	Mutation rewiring degron network	0.1111
p.R218C	SIDM00760	Small Cell Lung Carcinoma	GDSC	LPPYPE	LIG_APCC_ABBA_1	226:231	Mutation rewiring degron network	0.1111
p.R218C	SIDM01173	Rhabdomyosarcoma	GDSC	LPPYPE	LIG_APCC_ABBA_1	226:231	Mutation rewiring degron network	0.1111
p.R218C	SIDM00628	Breast Carcinoma	GDSC	LPPYPE	LIG_APCC_ABBA_1	226:231	Mutation rewiring degron network	0.1111
p.P228L	SIDM00934	Pancreatic Carcinoma	GDSC	LPPYPE	LIG_APCC_ABBA_1	226:231	Mutation altering degron motif	0.6471
p.P228L	SIDM01774	Pancreatic Carcinoma	GDSC	LPPYPE	LIG_APCC_ABBA_1	226:231	Mutation altering degron motif	0.6471
p.P228L	ACH-000205	Pancreatic Cancer	CCLE	LPPYPE	LIG_APCC_ABBA_1	226:231	Mutation altering degron motif	0.6471
p.P228L	ACH-000354	Pancreatic Cancer	CCLE	LPPYPE	LIG_APCC_ABBA_1	226:231	Mutation altering degron motif	0.6471
p.P228L	ACH-001970	Metastasis	CCLE	LPPYPE	LIG_APCC_ABBA_1	226:231	Mutation altering degron motif	0.6471
p.P228L	CAPAN-1	pancreas	COSMIC	LPPYPE	LIG_APCC_ABBA_1	226:231	Mutation altering degron motif	0.6471
p.M222V	ACH-001645	Skin Cancer	CCLE	LPPYPE	LIG_APCC_ABBA_1	226:231	Mutation rewiring degron network	0.2222

Kaplan plot for ZNF783 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF783

UniProt ID: Q6ZMS7

Entrez ID: 100289678

Protein name: Zinc finger protein 783

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ZNF783 in