DegronMD

Uniprot ID: Q6ZMS7

Source protein: Zinc finger protein 783

Source gene: ZNF783

Class: LIG_APCC_ABBA_1

Location: 226:231

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9491

ASA_SCORE: 99.3167

COIL: 0.8898

CONS_SCORE: 0.8586

DSS_SCORE: 0.7062

HELIX: 0.0603

FCONS_SCORE: 1.3381

RIG_SCORE: 0.6161

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H232N	TCGA-43-8118	LUSC	TCGA	LPPYPE	LIG_APCC_ABBA_1	0.3056
p.H232N	DO45471	LUSC	ICGC	LPPYPE	LIG_APCC_ABBA_1	0.3056
p.G217R	TCGA-64-1676	LUAD	TCGA	LPPYPE	LIG_APCC_ABBA_1	0.0833
p.G217R	DO23629	LUAD	ICGC	LPPYPE	LIG_APCC_ABBA_1	0.0833
p.R220K	TCGA-AB-2868	LAML	TCGA	LPPYPE	LIG_APCC_ABBA_1	0.1667
p.R220K	DO21595	LAML	ICGC	LPPYPE	LIG_APCC_ABBA_1	0.1667
p.R218H	TCGA-AX-A06F	UCEC	TCGA	LPPYPE	LIG_APCC_ABBA_1	0.1111
p.R218H	DO41752	UCEC	ICGC	LPPYPE	LIG_APCC_ABBA_1	0.1111
p.L233I	TCGA-AX-A3FS	UCEC	TCGA	LPPYPE	LIG_APCC_ABBA_1	0.2778
p.L233I	DO40879	UCEC	ICGC	LPPYPE	LIG_APCC_ABBA_1	0.2778
p.L233I	SIDM02021	Esophageal Carcinoma	GDSC	LPPYPE	LIG_APCC_ABBA_1	0.2778
p.P230Q	TCGA-ER-A196	SKCM	TCGA	LPPYPE	LIG_APCC_ABBA_1	0.5924
p.P230Q	DO47474	SKCM	ICGC	LPPYPE	LIG_APCC_ABBA_1	0.5924
p.P230L	TCGA-FW-A3R5	SKCM	TCGA	LPPYPE	LIG_APCC_ABBA_1	0.6471
p.P230L	DO37406	SKCM	ICGC	LPPYPE	LIG_APCC_ABBA_1	0.6471
p.L233R	DO233663	GACA	ICGC	LPPYPE	LIG_APCC_ABBA_1	0.2778
p.R218L	DO229045	LICA	ICGC	LPPYPE	LIG_APCC_ABBA_1	0.1111
p.R218C	SIDM00654	Small Cell Lung Carcinoma	GDSC	LPPYPE	LIG_APCC_ABBA_1	0.1111
p.R218C	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	LPPYPE	LIG_APCC_ABBA_1	0.1111
p.R218C	SIDM00907	Burkitt's Lymphoma	GDSC	LPPYPE	LIG_APCC_ABBA_1	0.1111
p.R218C	SIDM00760	Small Cell Lung Carcinoma	GDSC	LPPYPE	LIG_APCC_ABBA_1	0.1111
p.R218C	SIDM01173	Rhabdomyosarcoma	GDSC	LPPYPE	LIG_APCC_ABBA_1	0.1111
p.R218C	SIDM00628	Breast Carcinoma	GDSC	LPPYPE	LIG_APCC_ABBA_1	0.1111
p.P228L	SIDM00934	Pancreatic Carcinoma	GDSC	LPPYPE	LIG_APCC_ABBA_1	0.6471
p.P228L	SIDM01774	Pancreatic Carcinoma	GDSC	LPPYPE	LIG_APCC_ABBA_1	0.6471
p.P228L	ACH-000205	Pancreatic Cancer	CCLE	LPPYPE	LIG_APCC_ABBA_1	0.6471
p.P228L	ACH-000354	Pancreatic Cancer	CCLE	LPPYPE	LIG_APCC_ABBA_1	0.6471
p.P228L	ACH-001970	Metastasis	CCLE	LPPYPE	LIG_APCC_ABBA_1	0.6471
p.P228L	CAPAN-1	pancreas	COSMIC	LPPYPE	LIG_APCC_ABBA_1	0.6471
p.M222V	ACH-001645	Skin Cancer	CCLE	LPPYPE	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZMS7	Zinc finger protein 783	LIG_APCC_ABBA_1	226:231	LPPYPE	APC,CDC20,FZR1	0.9491	More...
Q9H0K4	Radial spoke head protein 6 homolog A	LIG_APCC_ABBA_1	4:9	LPPYPE	APC,CDC20,FZR1	0.9572	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LPPYPE

Degron related mutations and impact score

Drug responses associated with ZNF783 mutations

All proteins holding degron of LPPYPE