DegronMD

Uniprot ID: Q9H0K4

Source protein: Radial spoke head protein 6 homolog A

Source gene: RSPH6A

Class: LIG_APCC_ABBA_1

Location: 4:9

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9572

ASA_SCORE: 108.3167

COIL: 0.9768

CONS_SCORE: 0.1536

DSS_SCORE: 0.9781

HELIX: 0.0132

FCONS_SCORE: 1.0796

RIG_SCORE: 0.6147

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R10C	TCGA-AJ-A3BG	UCEC	TCGA	LPPYPE	LIG_APCC_ABBA_1	0.3056
p.R10C	DO42633	UCEC	ICGC	LPPYPE	LIG_APCC_ABBA_1	0.3056
p.R10H	TCGA-AP-A1DR	UCEC	TCGA	LPPYPE	LIG_APCC_ABBA_1	0.3056
p.R10H	DO43747	UCEC	ICGC	LPPYPE	LIG_APCC_ABBA_1	0.3056
p.P8H	TCGA-AX-A2HD	UCEC	TCGA	LPPYPE	LIG_APCC_ABBA_1	0.6583
p.P8H	DO42608	UCEC	ICGC	LPPYPE	LIG_APCC_ABBA_1	0.6583
p.P16S	TCGA-D3-A51G	SKCM	TCGA	LPPYPE	LIG_APCC_ABBA_1	0.1389
p.P16S	DO47700	SKCM	ICGC	LPPYPE	LIG_APCC_ABBA_1	0.1389
p.R19G	TCGA-FI-A2D0	UCEC	TCGA	LPPYPE	LIG_APCC_ABBA_1	0.0556
p.R19G	DO43891	UCEC	ICGC	LPPYPE	LIG_APCC_ABBA_1	0.0556
p.R18Q	TCGA-HU-A4H4	STAD	TCGA	LPPYPE	LIG_APCC_ABBA_1	0.0833
p.R18Q	DO47721	STAD	ICGC	LPPYPE	LIG_APCC_ABBA_1	0.0833
p.A8V	DO234304	ESAD	ICGC	LPPYPE	LIG_APCC_ABBA_1	0.6936
p.A8V	DO233647	GACA	ICGC	LPPYPE	LIG_APCC_ABBA_1	0.6936
p.Q2R	DO23108	LINC	ICGC	LPPYPE	LIG_APCC_ABBA_1	0.2778
p.Q2R	DO45041	LINC	ICGC	LPPYPE	LIG_APCC_ABBA_1	0.2778
p.Q11H	DO26488	LUSC	ICGC	LPPYPE	LIG_APCC_ABBA_1	0.2778
p.A13P	DO26647	LUSC	ICGC	LPPYPE	LIG_APCC_ABBA_1	0.2222
p.T4I	DO37819	SKCM	ICGC	LPPYPE	LIG_APCC_ABBA_1	0.7078
p.R19K	DO229253	THCA	ICGC	LPPYPE	LIG_APCC_ABBA_1	0.0556
p.P5S	SIDM00217	Colorectal Carcinoma	GDSC	LPPYPE	LIG_APCC_ABBA_1	0.5641
p.P5S	ACH-000999	Colon/Colorectal Cancer	CCLE	LPPYPE	LIG_APCC_ABBA_1	0.5641
p.P5S	SNU-1040	large_intestine	COSMIC	LPPYPE	LIG_APCC_ABBA_1	0.5641
p.R17G	YT	haematopoietic_and_lymphoid_tissue	COSMIC	LPPYPE	LIG_APCC_ABBA_1	0.1111
p.M7R	PC-14	lung	COSMIC	LPPYPE	LIG_APCC_ABBA_1	0.8632
p.G19R	SW684	soft_tissue	COSMIC	LPPYPE	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZMS7	Zinc finger protein 783	LIG_APCC_ABBA_1	226:231	LPPYPE	APC,CDC20,FZR1	0.9491	More...
Q9H0K4	Radial spoke head protein 6 homolog A	LIG_APCC_ABBA_1	4:9	LPPYPE	APC,CDC20,FZR1	0.9572	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons