DegronMD - Q9H0K4(RSPH6A)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R10C	TCGA-AJ-A3BG	UCEC	TCGA	LPPYPE	LIG_APCC_ABBA_1	4:9	Mutation rewiring degron network	0.3056
p.R10C	DO42633	UCEC	ICGC	LPPYPE	LIG_APCC_ABBA_1	4:9	Mutation rewiring degron network	0.3056
p.R10H	TCGA-AP-A1DR	UCEC	TCGA	LPPYPE	LIG_APCC_ABBA_1	4:9	Mutation rewiring degron network	0.3056
p.R10H	DO43747	UCEC	ICGC	LPPYPE	LIG_APCC_ABBA_1	4:9	Mutation rewiring degron network	0.3056
p.P8H	TCGA-AX-A2HD	UCEC	TCGA	LPPYPE	LIG_APCC_ABBA_1	4:9	Mutation altering degron motif	0.6583
p.P8H	DO42608	UCEC	ICGC	LPPYPE	LIG_APCC_ABBA_1	4:9	Mutation altering degron motif	0.6583
p.P16S	TCGA-D3-A51G	SKCM	TCGA	LPPYPE	LIG_APCC_ABBA_1	4:9	Mutation rewiring degron network	0.1389
p.P16S	DO47700	SKCM	ICGC	LPPYPE	LIG_APCC_ABBA_1	4:9	Mutation rewiring degron network	0.1389
p.P606L	TCGA-D5-6928	COAD	TCGA	PLLTPLSE	DEG_SCF_FBW7_2	590:597	Mutation rewiring degron network	0.0833
p.M602V	TCGA-DX-A2IZ	SARC	TCGA	PLLTPLSE	DEG_SCF_FBW7_2	590:597	Mutation rewiring degron network	0.1944
p.R19G	TCGA-FI-A2D0	UCEC	TCGA	LPPYPE	LIG_APCC_ABBA_1	4:9	Mutation rewiring degron network	0.0556
p.R19G	DO43891	UCEC	ICGC	LPPYPE	LIG_APCC_ABBA_1	4:9	Mutation rewiring degron network	0.0556
p.R18Q	TCGA-HU-A4H4	STAD	TCGA	LPPYPE	LIG_APCC_ABBA_1	4:9	Mutation rewiring degron network	0.0833
p.R18Q	DO47721	STAD	ICGC	LPPYPE	LIG_APCC_ABBA_1	4:9	Mutation rewiring degron network	0.0833
p.H603Y	TCGA-J4-8198	PRAD	TCGA	PLLTPLSE	DEG_SCF_FBW7_2	590:597	Mutation rewiring degron network	0.1667
p.A8V	DO234304	ESAD	ICGC	LPPYPE	LIG_APCC_ABBA_1	4:9	Mutation altering degron motif	0.6936
p.A8V	DO233647	GACA	ICGC	LPPYPE	LIG_APCC_ABBA_1	4:9	Mutation altering degron motif	0.6936
p.Q2R	DO23108	LINC	ICGC	LPPYPE	LIG_APCC_ABBA_1	4:9	Mutation rewiring degron network	0.2778
p.Q2R	DO45041	LINC	ICGC	LPPYPE	LIG_APCC_ABBA_1	4:9	Mutation rewiring degron network	0.2778
p.Q11H	DO26488	LUSC	ICGC	LPPYPE	LIG_APCC_ABBA_1	4:9	Mutation rewiring degron network	0.2778
p.A13P	DO26647	LUSC	ICGC	LPPYPE	LIG_APCC_ABBA_1	4:9	Mutation rewiring degron network	0.2222
p.T4I	DO37819	SKCM	ICGC	LPPYPE	LIG_APCC_ABBA_1	4:9	Mutation altering degron motif	0.7078
p.R19K	DO229253	THCA	ICGC	LPPYPE	LIG_APCC_ABBA_1	4:9	Mutation rewiring degron network	0.0556
p.A599T	SIDM00793	Burkitt's Lymphoma	GDSC	PLLTPLSE	DEG_SCF_FBW7_2	590:597	Mutation rewiring degron network	0.2778
p.A599T	ACH-002236	Lymphoma	CCLE	PLLTPLSE	DEG_SCF_FBW7_2	590:597	Mutation rewiring degron network	0.2778
p.A599T	EB-3	haematopoietic and lymphoid tissue	COSMIC	PLLTPLSE	DEG_SCF_FBW7_2	590:597	Mutation rewiring degron network	0.2778
p.P5S	SIDM00217	Colorectal Carcinoma	GDSC	LPPYPE	LIG_APCC_ABBA_1	4:9	Mutation altering degron motif	0.5641
p.P5S	ACH-000999	Colon/Colorectal Cancer	CCLE	LPPYPE	LIG_APCC_ABBA_1	4:9	Mutation altering degron motif	0.5641
p.P5S	SNU-1040	large intestine	COSMIC	LPPYPE	LIG_APCC_ABBA_1	4:9	Mutation altering degron motif	0.5641
p.L604V	SIDM00387	Neuroblastoma	GDSC	PLLTPLSE	DEG_SCF_FBW7_2	590:597	Mutation rewiring degron network	0.1389
p.L604V	ACH-000078	Neuroblastoma	CCLE	PLLTPLSE	DEG_SCF_FBW7_2	590:597	Mutation rewiring degron network	0.1389
p.L604V	MHH-NB-11	autonomic ganglia	COSMIC	PLLTPLSE	DEG_SCF_FBW7_2	590:597	Mutation rewiring degron network	0.1389
p.R17G	YT	haematopoietic and lymphoid tissue	COSMIC	LPPYPE	LIG_APCC_ABBA_1	4:9	Mutation rewiring degron network	0.1111
p.M7R	PC-14	lung	COSMIC	LPPYPE	LIG_APCC_ABBA_1	4:9	Mutation altering degron motif	0.8632
p.G19R	SW684	soft tissue	COSMIC	LPPYPE	LIG_APCC_ABBA_1	4:9	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RSPH6A

UniProt ID: Q9H0K4

Entrez ID: 81492

Protein name: Radial spoke head protein 6 homolog A (Radial spoke head-like protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RSPH6A in