DegronMD

Uniprot ID: Q9H0K4

Source protein: Radial spoke head protein 6 homolog A

Source gene: RSPH6A

Class: DEG_SCF_FBW7_2

Location: 590:597

E3 ligase: FBXW7

DEGRON score: 0.9989

ASA_SCORE: 67.275

COIL: 0.753

CONS_SCORE: 0.6721

DSS_SCORE: 0.5806

HELIX: 0.0847

FCONS_SCORE: 1.2388

RIG_SCORE: 0.73

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A599T	SIDM00793	Burkitt's Lymphoma	GDSC	PLLTPLSE	DEG_SCF_FBW7_2	0.2778
p.A599T	ACH-002236	Lymphoma	CCLE	PLLTPLSE	DEG_SCF_FBW7_2	0.2778
p.A599T	EB-3	haematopoietic_and_lymphoid_tissue	COSMIC	PLLTPLSE	DEG_SCF_FBW7_2	0.2778
p.M602V	TCGA-DX-A2IZ	SARC	TCGA	PLLTPLSE	DEG_SCF_FBW7_2	0.1944
p.H603Y	TCGA-J4-8198	PRAD	TCGA	PLLTPLSE	DEG_SCF_FBW7_2	0.1667
p.L604V	SIDM00387	Neuroblastoma	GDSC	PLLTPLSE	DEG_SCF_FBW7_2	0.1389
p.L604V	ACH-000078	Neuroblastoma	CCLE	PLLTPLSE	DEG_SCF_FBW7_2	0.1389
p.L604V	MHH-NB-11	autonomic_ganglia	COSMIC	PLLTPLSE	DEG_SCF_FBW7_2	0.1389
p.P606L	TCGA-D5-6928	COAD	TCGA	PLLTPLSE	DEG_SCF_FBW7_2	0.0833

Showing 1 to 9 of 9 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H0K4	Radial spoke head protein 6 homolog A	DEG_SCF_FBW7_2	590:597	PLLTPLSE	FBXW7	0.9989	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons