DegronMD - Q6ZMW3(EML6)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S616G	TCGA-A8-A08S	BRCA	TCGA	EESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.3056
p.S616G	DO3140	BRCA	ICGC	EESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.3056
p.E634K	TCGA-AC-A23H	BRCA	TCGA	EESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.1944
p.E634K	DO2401	BRCA	ICGC	EESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.1944
p.E628K	TCGA-AX-A2HC	UCEC	TCGA	EESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation altering degron motif	0.7022
p.E628K	DO228948	LICA	ICGC	EESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation altering degron motif	0.7022
p.E628K	DO49178	PACA	ICGC	EESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation altering degron motif	0.7022
p.E628K	DO41572	UCEC	ICGC	EESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation altering degron motif	0.7022
p.E628K	ACH-001991	Primary	CCLE	EESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation altering degron motif	0.7022
p.D630E	TCGA-EI-6917	READ	TCGA	EESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.3056
p.D630E	DO36881	READ	ICGC	EESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.3056
p.I639V	TCGA-LN-A49P	ESCA	TCGA	EESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.0556
p.S624F	SIDM00555	Glioblastoma	GDSC	EESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation altering degron motif	0.6871
p.S624F	ACH-000631	Brain Cancer	CCLE	EESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation altering degron motif	0.6871
p.S624F	KS-1	central nervous system	COSMIC	EESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation altering degron motif	0.6871
p.Y615F	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	EESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.2778
p.E634D	SIDM00077	Oral Cavity Carcinoma	GDSC	EESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.1944
p.E634D	ACH-001331	Head and Neck Cancer	CCLE	EESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.1944
p.E634D	BICR10	upper aerodigestive tract	COSMIC	EESDSDLSDVPEL	DEG_COP1_1	617:629	Mutation rewiring degron network	0.1944

Kaplan plot for EML6 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EML6

UniProt ID: Q6ZMW3

Entrez ID: 400954

Protein name: Echinoderm microtubule-associated protein-like 6 (EMAP-6) (Echinoderm microtubule-associated protein-like 5-like)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for EML6 in