DegronMD

Uniprot ID: Q6ZMW3

Source protein: Echinoderm microtubule-associated protein-like 6

Source gene: EML6

Class: DEG_COP1_1

Location: 617:629

E3 ligase: COP1

DEGRON score: 0.989

ASA_SCORE: 64.1923

COIL: 0.7222

CONS_SCORE: 0.5981

DSS_SCORE: 0.7773

HELIX: 0.1605

FCONS_SCORE: 1.179

RIG_SCORE: 0.661

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S616G	TCGA-A8-A08S	BRCA	TCGA	EESDSDLSDVPEL	DEG_COP1_1	0.3056
p.S616G	DO3140	BRCA	ICGC	EESDSDLSDVPEL	DEG_COP1_1	0.3056
p.E634K	TCGA-AC-A23H	BRCA	TCGA	EESDSDLSDVPEL	DEG_COP1_1	0.1944
p.E634K	DO2401	BRCA	ICGC	EESDSDLSDVPEL	DEG_COP1_1	0.1944
p.E628K	TCGA-AX-A2HC	UCEC	TCGA	EESDSDLSDVPEL	DEG_COP1_1	0.7022
p.E628K	DO228948	LICA	ICGC	EESDSDLSDVPEL	DEG_COP1_1	0.7022
p.E628K	DO49178	PACA	ICGC	EESDSDLSDVPEL	DEG_COP1_1	0.7022
p.E628K	DO41572	UCEC	ICGC	EESDSDLSDVPEL	DEG_COP1_1	0.7022
p.E628K	ACH-001991	Primary	CCLE	EESDSDLSDVPEL	DEG_COP1_1	0.7022
p.D630E	TCGA-EI-6917	READ	TCGA	EESDSDLSDVPEL	DEG_COP1_1	0.3056
p.D630E	DO36881	READ	ICGC	EESDSDLSDVPEL	DEG_COP1_1	0.3056
p.I639V	TCGA-LN-A49P	ESCA	TCGA	EESDSDLSDVPEL	DEG_COP1_1	0.0556
p.S624F	SIDM00555	Glioblastoma	GDSC	EESDSDLSDVPEL	DEG_COP1_1	0.6871
p.S624F	ACH-000631	Brain Cancer	CCLE	EESDSDLSDVPEL	DEG_COP1_1	0.6871
p.S624F	KS-1	central_nervous_system	COSMIC	EESDSDLSDVPEL	DEG_COP1_1	0.6871
p.Y615F	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	EESDSDLSDVPEL	DEG_COP1_1	0.2778
p.E634D	SIDM00077	Oral Cavity Carcinoma	GDSC	EESDSDLSDVPEL	DEG_COP1_1	0.1944
p.E634D	ACH-001331	Head and Neck Cancer	CCLE	EESDSDLSDVPEL	DEG_COP1_1	0.1944
p.E634D	BICR10	upper_aerodigestive_tract	COSMIC	EESDSDLSDVPEL	DEG_COP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZMW3	Echinoderm microtubule-associated protein-like 6	DEG_COP1_1	617:629	EESDSDLSDVPEL	COP1	0.989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons