DegronMD - Q6ZN28(MACC1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P492L	TCGA-4Z-AA84	BLCA	TCGA	ITTPDPT	DEG_SCF_FBW7_1	502:508	Mutation rewiring degron network	0.0556
p.P492L	DO218988	BLCA	ICGC	ITTPDPT	DEG_SCF_FBW7_1	502:508	Mutation rewiring degron network	0.0556
p.P492L	DO220900	MELA	ICGC	ITTPDPT	DEG_SCF_FBW7_1	502:508	Mutation rewiring degron network	0.0556
p.P507Q	TCGA-CV-7568	HNSC	TCGA	ITTPDPT	DEG_SCF_FBW7_1	502:508	Mutation altering degron motif	0.5924
p.P507Q	DO14160	HNSC	ICGC	ITTPDPT	DEG_SCF_FBW7_1	502:508	Mutation altering degron motif	0.5924
p.D506N	TCGA-EE-A3JA	SKCM	TCGA	ITTPDPT	DEG_SCF_FBW7_1	502:508	Mutation altering degron motif	0.5821
p.D506N	DO47625	SKCM	ICGC	ITTPDPT	DEG_SCF_FBW7_1	502:508	Mutation altering degron motif	0.5821
p.S515L	DO229010	COCA	ICGC	ITTPDPT	DEG_SCF_FBW7_1	502:508	Mutation blocking phosphorylation signal	0.5833
p.S515L	DO229013	COCA	ICGC	ITTPDPT	DEG_SCF_FBW7_1	502:508	Mutation blocking phosphorylation signal	0.5833
p.S515L	DO229016	COCA	ICGC	ITTPDPT	DEG_SCF_FBW7_1	502:508	Mutation blocking phosphorylation signal	0.5833
p.S515L	DO229003	COCA	ICGC	ITTPDPT	DEG_SCF_FBW7_1	502:508	Mutation blocking phosphorylation signal	0.5833
p.S515A	DO233747	GACA	ICGC	ITTPDPT	DEG_SCF_FBW7_1	502:508	Mutation blocking phosphorylation signal	0.5833
p.L511R	DO23154	LINC	ICGC	ITTPDPT	DEG_SCF_FBW7_1	502:508	Mutation rewiring degron network	0.25
p.L511R	DO45085	LINC	ICGC	ITTPDPT	DEG_SCF_FBW7_1	502:508	Mutation rewiring degron network	0.25
p.T508A	DO220891	MELA	ICGC	ITTPDPT	DEG_SCF_FBW7_1	502:508	Mutation altering degron motif	0.7139
p.P507S	DO222702	MELA	ICGC	ITTPDPT	DEG_SCF_FBW7_1	502:508	Mutation altering degron motif	0.5641
p.R513K	DO222837	MELA	ICGC	ITTPDPT	DEG_SCF_FBW7_1	502:508	Mutation rewiring degron network	0.1944
p.D506G	SIDM01090	Colorectal Carcinoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	502:508	Mutation altering degron motif	0.6087
p.D506G	ACH-000943	Colon/Colorectal Cancer	CCLE	ITTPDPT	DEG_SCF_FBW7_1	502:508	Mutation altering degron motif	0.6087
p.D506G	RKO	large intestine	COSMIC	ITTPDPT	DEG_SCF_FBW7_1	502:508	Mutation altering degron motif	0.6087
p.T503A	SIDM01608	Endometrial Carcinoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	502:508	Mutation altering degron motif	0.6028
p.T503A	ACH-000990	Endometrial/Uterine Cancer	CCLE	ITTPDPT	DEG_SCF_FBW7_1	502:508	Mutation altering degron motif	0.6028

Kaplan plot for MACC1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MACC1

UniProt ID: Q6ZN28

Entrez ID: 346389

Protein name: Metastasis-associated in colon cancer protein 1 (SH3 domain-containing protein 7a5)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for MACC1 in