DegronMD

Uniprot ID: Q6ZN28

Source protein: Metastasis-associated in colon cancer protein 1

Source gene: MACC1

Class: DEG_SCF_FBW7_1

Location: 502:508

E3 ligase: FBXW7

DEGRON score: 0.6989

ASA_SCORE: 62.6857

COIL: 0.768

CONS_SCORE: 0.6279

DSS_SCORE: 0.5418

HELIX: 0.0066

FCONS_SCORE: 1.4014

RIG_SCORE: 0.7143

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P492L	TCGA-4Z-AA84	BLCA	TCGA	ITTPDPT	DEG_SCF_FBW7_1	0.0556
p.P492L	DO218988	BLCA	ICGC	ITTPDPT	DEG_SCF_FBW7_1	0.0556
p.P492L	DO220900	MELA	ICGC	ITTPDPT	DEG_SCF_FBW7_1	0.0556
p.P507Q	TCGA-CV-7568	HNSC	TCGA	ITTPDPT	DEG_SCF_FBW7_1	0.5924
p.P507Q	DO14160	HNSC	ICGC	ITTPDPT	DEG_SCF_FBW7_1	0.5924
p.D506N	TCGA-EE-A3JA	SKCM	TCGA	ITTPDPT	DEG_SCF_FBW7_1	0.5821
p.D506N	DO47625	SKCM	ICGC	ITTPDPT	DEG_SCF_FBW7_1	0.5821
p.S515L	DO229010	COCA	ICGC	ITTPDPT	DEG_SCF_FBW7_1	0.5833
p.S515L	DO229013	COCA	ICGC	ITTPDPT	DEG_SCF_FBW7_1	0.5833
p.S515L	DO229016	COCA	ICGC	ITTPDPT	DEG_SCF_FBW7_1	0.5833
p.S515L	DO229003	COCA	ICGC	ITTPDPT	DEG_SCF_FBW7_1	0.5833
p.S515A	DO233747	GACA	ICGC	ITTPDPT	DEG_SCF_FBW7_1	0.5833
p.L511R	DO23154	LINC	ICGC	ITTPDPT	DEG_SCF_FBW7_1	0.25
p.L511R	DO45085	LINC	ICGC	ITTPDPT	DEG_SCF_FBW7_1	0.25
p.T508A	DO220891	MELA	ICGC	ITTPDPT	DEG_SCF_FBW7_1	0.7139
p.P507S	DO222702	MELA	ICGC	ITTPDPT	DEG_SCF_FBW7_1	0.5641
p.R513K	DO222837	MELA	ICGC	ITTPDPT	DEG_SCF_FBW7_1	0.1944
p.D506G	SIDM01090	Colorectal Carcinoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.6087
p.D506G	ACH-000943	Colon/Colorectal Cancer	CCLE	ITTPDPT	DEG_SCF_FBW7_1	0.6087
p.D506G	RKO	large_intestine	COSMIC	ITTPDPT	DEG_SCF_FBW7_1	0.6087
p.T503A	SIDM01608	Endometrial Carcinoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.6028
p.T503A	ACH-000990	Endometrial/Uterine Cancer	CCLE	ITTPDPT	DEG_SCF_FBW7_1	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P05231	Interleukin-6	DEG_SCF_FBW7_1	164:170	ITTPDPT	FBXW7	0.9626	More...
Q6ZN28	Metastasis-associated in colon cancer protein 1	DEG_SCF_FBW7_1	502:508	ITTPDPT	FBXW7	0.6989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons