DegronMD

Uniprot ID: P05231

Source protein: Interleukin-6

Source gene: IL6

Class: DEG_SCF_FBW7_1

Location: 164:170

E3 ligase: FBXW7

DEGRON score: 0.9626

ASA_SCORE: 78.7571

COIL: 0.8524

CONS_SCORE: 0.4549

DSS_SCORE: 0.3816

HELIX: 0.115

FCONS_SCORE: 1.017

RIG_SCORE: 0.7535

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D162E	DO229489	LAML	ICGC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM01265	Plasma Cell Myeloma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM01020	Plasma Cell Myeloma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM00253	Neuroblastoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM00234	Other Solid Cancers	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM00330	Neuroblastoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM01237	Hepatocellular Carcinoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM00565	Oral Cavity Carcinoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM00262	Ewing's Sarcoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM00057	Neuroblastoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM01201	Other Blood Cancers	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM00552	Rhabdomyosarcoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM00155	Head and Neck Carcinoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM01247	Burkitt's Lymphoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM00292	Small Cell Lung Carcinoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM01180	Hepatocellular Carcinoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM00516	Melanoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM00674	Non-Cancerous	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM00247	Gastric Carcinoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM00887	Other Solid Cancers	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM01049	Non-Cancerous	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM00438	B-Lymphoblastic Leukemia	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM00018	Acute Myeloid Leukemia	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM01061	Oral Cavity Carcinoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM00271	Gastric Carcinoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM00613	Glioblastoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM00999	Bladder Carcinoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM01879	Non-Cancerous	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM01059	Melanoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM00381	Cervical Carcinoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM00359	Colorectal Carcinoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM01449	Pancreatic Carcinoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.D162E	SIDM01494	Glioblastoma	GDSC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.L175R	DO230950	LUSC	ICGC	ITTPDPT	DEG_SCF_FBW7_1	0.1944
p.L175R	DO224638	LUSC	ICGC	ITTPDPT	DEG_SCF_FBW7_1	0.1944
p.R173H	SNU-81	large_intestine	COSMIC	ITTPDPT	DEG_SCF_FBW7_1	0.25
p.V160E	JEG-3	placenta	COSMIC	ITTPDPT	DEG_SCF_FBW7_1	0.2222
p.W162R	SNU-C5	large_intestine	COSMIC	ITTPDPT	DEG_SCF_FBW7_1	0.2778
p.V160A	NCI-H2196	lung	COSMIC	ITTPDPT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P05231	Interleukin-6	DEG_SCF_FBW7_1	164:170	ITTPDPT	FBXW7	0.9626	More...
Q6ZN28	Metastasis-associated in colon cancer protein 1	DEG_SCF_FBW7_1	502:508	ITTPDPT	FBXW7	0.6989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ITTPDPT

Degron related mutations and impact score

Drug responses associated with IL6 mutations

All proteins holding degron of ITTPDPT