DegronMD - Q6ZNF0(ACP7)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N146K	SIDM00424	B-Cell Non-Hodgkin's Lymphoma	GDSC	LAVFGD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.1944
p.N146K	SIDM00424	B-Cell Non-Hodgkin's Lymphoma	GDSC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	135:141	Mutation rewiring degron network	0.1944
p.N146K	SIDM00465	Ovarian Carcinoma	GDSC	LAVFGD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.1944
p.N146K	SIDM00465	Ovarian Carcinoma	GDSC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	135:141	Mutation rewiring degron network	0.1944
p.N146K	SIDM00260	Gastric Carcinoma	GDSC	LAVFGD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.1944
p.N146K	SIDM00260	Gastric Carcinoma	GDSC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	135:141	Mutation rewiring degron network	0.1944
p.N146K	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	LAVFGD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.1944
p.N146K	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	135:141	Mutation rewiring degron network	0.1944
p.N146K	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	LAVFGD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.1944
p.N146K	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	135:141	Mutation rewiring degron network	0.1944
p.N146K	SIDM00612	Glioma	GDSC	LAVFGD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.1944
p.N146K	SIDM00612	Glioma	GDSC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	135:141	Mutation rewiring degron network	0.1944
p.N146K	SIDM00609	Kidney Carcinoma	GDSC	LAVFGD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.1944
p.N146K	SIDM00609	Kidney Carcinoma	GDSC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	135:141	Mutation rewiring degron network	0.1944
p.N146K	SIDM00280	Gastric Carcinoma	GDSC	LAVFGD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.1944
p.N146K	SIDM00280	Gastric Carcinoma	GDSC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	135:141	Mutation rewiring degron network	0.1944
p.N146K	SIDM00561	Other Blood Cancers	GDSC	LAVFGD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.1944
p.N146K	SIDM00561	Other Blood Cancers	GDSC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	135:141	Mutation rewiring degron network	0.1944
p.N146K	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	LAVFGD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.1944
p.N146K	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	135:141	Mutation rewiring degron network	0.1944
p.N146K	SIDM00316	Glioblastoma	GDSC	LAVFGD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.1944
p.N146K	SIDM00316	Glioblastoma	GDSC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	135:141	Mutation rewiring degron network	0.1944
p.N146K	SIDM00248	Gastric Carcinoma	GDSC	LAVFGD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.1944
p.N146K	SIDM00248	Gastric Carcinoma	GDSC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	135:141	Mutation rewiring degron network	0.1944
p.N146K	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	LAVFGD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.1944
p.N146K	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	135:141	Mutation rewiring degron network	0.1944
p.N146K	SIDM01760	Rhabdomyosarcoma	GDSC	LAVFGD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.1944
p.N146K	SIDM01760	Rhabdomyosarcoma	GDSC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	135:141	Mutation rewiring degron network	0.1944
p.N146K	KNS-62	lung	COSMIC	LAVFGD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.1944
p.N146K	KNS-62	lung	COSMIC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	135:141	Mutation rewiring degron network	0.1944
p.N146K	U-698-M	haematopoietic and lymphoid tissue	COSMIC	LAVFGD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.1944
p.N146K	U-698-M	haematopoietic and lymphoid tissue	COSMIC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	135:141	Mutation rewiring degron network	0.1944
p.N146K	ECC10	stomach	COSMIC	LAVFGD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.1944
p.N146K	ECC10	stomach	COSMIC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	135:141	Mutation rewiring degron network	0.1944
p.N146K	OVMIU	ovary	COSMIC	LAVFGD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.1944
p.N146K	OVMIU	ovary	COSMIC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	135:141	Mutation rewiring degron network	0.1944
p.N146K	KYSE-70	oesophagus	COSMIC	LAVFGD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.1944
p.N146K	KYSE-70	oesophagus	COSMIC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	135:141	Mutation rewiring degron network	0.1944
p.N146K	YH-13	central nervous system	COSMIC	LAVFGD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.1944
p.N146K	YH-13	central nervous system	COSMIC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	135:141	Mutation rewiring degron network	0.1944
p.N146K	KMRC-20	kidney	COSMIC	LAVFGD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.1944
p.N146K	KMRC-20	kidney	COSMIC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	135:141	Mutation rewiring degron network	0.1944
p.N146K	TE-8	oesophagus	COSMIC	LAVFGD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.1944
p.N146K	TE-8	oesophagus	COSMIC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	135:141	Mutation rewiring degron network	0.1944
p.N146K	KINGS-1	central nervous system	COSMIC	LAVFGD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.1944
p.N146K	KINGS-1	central nervous system	COSMIC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	135:141	Mutation rewiring degron network	0.1944
p.N146K	MKN28	stomach	COSMIC	LAVFGD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.1944
p.N146K	MKN28	stomach	COSMIC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	135:141	Mutation rewiring degron network	0.1944
p.L142M	SIDM00220	Ovarian Carcinoma	GDSC	LAVFGD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.3056
p.L142M	SIDM00220	Ovarian Carcinoma	GDSC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	135:141	Mutation rewiring degron network	0.3056
p.L142M	OC-314	ovary	COSMIC	LAVFGD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.3056
p.L142M	OC-314	ovary	COSMIC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	135:141	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ACP7

UniProt ID: Q6ZNF0

Entrez ID: 390928

Protein name: Acid phosphatase type 7 (EC 3.1.3.2) (Purple acid phosphatase long form)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ACP7 in