DegronMD

Uniprot ID: Q6ZNF0

Source protein: Acid phosphatase type 7

Source gene: ACP7

Class: LIG_APCC_ABBAyCdc20_2

Location: 135:141

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6465

ASA_SCORE: 18.9714

COIL: 0.1449

CONS_SCORE: 0.5358

DSS_SCORE: 0.2912

HELIX: 0.01

FCONS_SCORE: 1.275

RIG_SCORE: 0.7905

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N146K	SIDM00424	B-Cell Non-Hodgkin's Lymphoma	GDSC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N146K	SIDM00465	Ovarian Carcinoma	GDSC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N146K	SIDM00260	Gastric Carcinoma	GDSC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N146K	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N146K	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N146K	SIDM00612	Glioma	GDSC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N146K	SIDM00609	Kidney Carcinoma	GDSC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N146K	SIDM00280	Gastric Carcinoma	GDSC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N146K	SIDM00561	Other Blood Cancers	GDSC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N146K	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N146K	SIDM00316	Glioblastoma	GDSC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N146K	SIDM00248	Gastric Carcinoma	GDSC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N146K	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N146K	SIDM01760	Rhabdomyosarcoma	GDSC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N146K	KNS-62	lung	COSMIC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N146K	U-698-M	haematopoietic_and_lymphoid_tissue	COSMIC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N146K	ECC10	stomach	COSMIC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N146K	OVMIU	ovary	COSMIC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N146K	KYSE-70	oesophagus	COSMIC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N146K	YH-13	central_nervous_system	COSMIC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N146K	KMRC-20	kidney	COSMIC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N146K	TE-8	oesophagus	COSMIC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N146K	KINGS-1	central_nervous_system	COSMIC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N146K	MKN28	stomach	COSMIC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	0.1944
p.L142M	SIDM00220	Ovarian Carcinoma	GDSC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.L142M	OC-314	ovary	COSMIC	RLAVFGD	LIG_APCC_ABBAyCdc20_2	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RLAVFGD

Degron related mutations and impact score

Drug responses associated with ACP7 mutations

All proteins holding degron of RLAVFGD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZNF0	Acid phosphatase type 7	LIG_APCC_ABBAyCdc20_2	135:141	RLAVFGD	APC,CDC20,FZR1	0.6465	More...