DegronMD - Q6ZNG0(ZNF620)

FUNCTION: May be involved in transcriptional regulation.

GO - Biological processes (BP): negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription by RNA polymerase II [GO:0006357]

GO - Molecular function (MF): DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]

GO - Cellular component (CC): nucleus [GO:0005634]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
GREALRGIC	DEG_APCC_DBOX_1	APC,CDC20,FZR1	Zinc finger protein 620	79:87	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G79C	DO229032	LICA	ICGC	GREALRGIC	DEG_APCC_DBOX_1	79:87	Mutation altering degron motif	0.6489
p.G79V	DO229041	LICA	ICGC	GREALRGIC	DEG_APCC_DBOX_1	79:87	Mutation altering degron motif	0.6421
p.G79D	SIDM02049	Pancreatic Carcinoma	GDSC	GREALRGIC	DEG_APCC_DBOX_1	79:87	Mutation altering degron motif	0.6087
p.C87Y	DO222684	ESCA	ICGC	GREALRGIC	DEG_APCC_DBOX_1	79:87	Mutation altering degron motif	0.5976
p.E81D	SIDM00969	Ovarian Carcinoma	GDSC	GREALRGIC	DEG_APCC_DBOX_1	79:87	Mutation altering degron motif	0.5647
p.M78I	DO229028	LICA	ICGC	GREALRGIC	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.3056
p.G89V	TCGA-EE-A2M7	SKCM	TCGA	GREALRGIC	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.2778
p.G89V	DO37847	SKCM	ICGC	GREALRGIC	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.2778
p.E91K	TCGA-XF-A8HE	BLCA	TCGA	GREALRGIC	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.2222
p.E91K	DO49797	BLCA	ICGC	GREALRGIC	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.2222
p.P74S	TCGA-EB-A550	SKCM	TCGA	GREALRGIC	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.1944
p.P74S	DO47265	SKCM	ICGC	GREALRGIC	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.1944
p.D73N	TCGA-AJ-A5DW	UCEC	TCGA	GREALRGIC	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.1667
p.D73N	DO50075	UCEC	ICGC	GREALRGIC	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.1667
p.D73A	TCGA-DM-A1HB	COAD	TCGA	GREALRGIC	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.1667
p.L72F	SIDM01763	Rhabdomyosarcoma	GDSC	GREALRGIC	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.1389
p.G71V	DO228952	LICA	ICGC	GREALRGIC	DEG_APCC_DBOX_1	79:87	Mutation rewiring degron network	0.1111

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No resistance data available for this Degron.

Kaplan plot for ZNF620 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF620

UniProt ID: Q6ZNG0

Entrez ID: 253639

Protein name: Zinc finger protein 620

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for ZNF620 in