DegronMD

Uniprot ID: Q6ZNG0

Source protein: Zinc finger protein 620

Source gene: ZNF620

Class: DEG_APCC_DBOX_1

Location: 79:87

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6438

ASA_SCORE: 68.0667

COIL: 0.5971

CONS_SCORE: 0

DSS_SCORE: 0.5509

HELIX: 0.1454

FCONS_SCORE: 0

RIG_SCORE: 0.7292

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D73N	TCGA-AJ-A5DW	UCEC	TCGA	GREALRGIC	DEG_APCC_DBOX_1	0.1667
p.D73N	DO50075	UCEC	ICGC	GREALRGIC	DEG_APCC_DBOX_1	0.1667
p.D73A	TCGA-DM-A1HB	COAD	TCGA	GREALRGIC	DEG_APCC_DBOX_1	0.1667
p.P74S	TCGA-EB-A550	SKCM	TCGA	GREALRGIC	DEG_APCC_DBOX_1	0.1944
p.P74S	DO47265	SKCM	ICGC	GREALRGIC	DEG_APCC_DBOX_1	0.1944
p.G89V	TCGA-EE-A2M7	SKCM	TCGA	GREALRGIC	DEG_APCC_DBOX_1	0.2778
p.G89V	DO37847	SKCM	ICGC	GREALRGIC	DEG_APCC_DBOX_1	0.2778
p.E91K	TCGA-XF-A8HE	BLCA	TCGA	GREALRGIC	DEG_APCC_DBOX_1	0.2222
p.E91K	DO49797	BLCA	ICGC	GREALRGIC	DEG_APCC_DBOX_1	0.2222
p.C87Y	DO222684	ESCA	ICGC	GREALRGIC	DEG_APCC_DBOX_1	0.5976
p.G71V	DO228952	LICA	ICGC	GREALRGIC	DEG_APCC_DBOX_1	0.1111
p.M78I	DO229028	LICA	ICGC	GREALRGIC	DEG_APCC_DBOX_1	0.3056
p.G79C	DO229032	LICA	ICGC	GREALRGIC	DEG_APCC_DBOX_1	0.6489
p.G79V	DO229041	LICA	ICGC	GREALRGIC	DEG_APCC_DBOX_1	0.6421
p.G79D	SIDM02049	Pancreatic Carcinoma	GDSC	GREALRGIC	DEG_APCC_DBOX_1	0.6087
p.E81D	SIDM00969	Ovarian Carcinoma	GDSC	GREALRGIC	DEG_APCC_DBOX_1	0.5647
p.L72F	SIDM01763	Rhabdomyosarcoma	GDSC	GREALRGIC	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZNG0	Zinc finger protein 620	DEG_APCC_DBOX_1	79:87	GREALRGIC	APC,CDC20,FZR1	0.6438	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons