DegronMD - Q6ZNL6(FGD5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R575M	TCGA-19-5956	GBM	TCGA	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation rewiring degron network	0.0556
p.D572G	TCGA-A5-A0G2	UCEC	TCGA	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation rewiring degron network	0.1389
p.E557D	TCGA-AX-A06F	UCEC	TCGA	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation rewiring degron network	0.25
p.E557D	TCGA-EO-A22U	UCEC	TCGA	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation rewiring degron network	0.25
p.Q564K	TCGA-CV-7252	HNSC	TCGA	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation altering degron motif	0.5833
p.Q564K	ACH-000901	Lung Cancer	CCLE	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation altering degron motif	0.5833
p.H574N	TCGA-EE-A2M7	SKCM	TCGA	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation rewiring degron network	0.0833
p.E567Q	TCGA-UY-A78K	BLCA	TCGA	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation rewiring degron network	0.2778
p.E567K	TCGA-XX-A89A	BRCA	TCGA	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation rewiring degron network	0.2778
p.E575K	DO8898	COAD	ICGC	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation rewiring degron network	0.0556
p.E575K	DO220875	MELA	ICGC	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation rewiring degron network	0.0556
p.E575K	DO37433	SKCM	ICGC	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation rewiring degron network	0.0556
p.A556P	DO26425	LUSC	ICGC	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation rewiring degron network	0.2222
p.L570P	DO42033	UCEC	ICGC	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation rewiring degron network	0.1944
p.A554V	DO43186	UCEC	ICGC	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation rewiring degron network	0.1667
p.A554V	DO42608	UCEC	ICGC	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation rewiring degron network	0.1667
p.A554V	DO41235	UCEC	ICGC	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation rewiring degron network	0.1667
p.A558T	DO41871	UCEC	ICGC	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation rewiring degron network	0.2778
p.A558T	DO41235	UCEC	ICGC	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation rewiring degron network	0.2778
p.A558T	SW48	large intestine	COSMIC	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation rewiring degron network	0.2778
p.A569T	DO42472	UCEC	ICGC	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation rewiring degron network	0.2222
p.P566T	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation rewiring degron network	0.3056
p.P566T	ACH-000843	Lung Cancer	CCLE	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation rewiring degron network	0.3056
p.P566T	HARA	lung	COSMIC	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation rewiring degron network	0.3056
p.P566R	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation rewiring degron network	0.3056
p.P566R	ACH-000843	Lung Cancer	CCLE	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation rewiring degron network	0.3056
p.P566R	HARA	lung	COSMIC	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation rewiring degron network	0.3056
p.V562M	SIDM00090	Ovarian Carcinoma	GDSC	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation altering degron motif	0.6097
p.S550P	SIDM00217	Colorectal Carcinoma	GDSC	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation rewiring degron network	0.0556
p.S550P	ACH-000999	Colon/Colorectal Cancer	CCLE	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation rewiring degron network	0.0556
p.S550P	SNU-1040	large intestine	COSMIC	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation rewiring degron network	0.0556
p.V560A	ACH-002926	Unknown	CCLE	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation altering degron motif	0.6936
p.A558V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	VSVYQE	LIG_APCC_ABBA_1	560:565	Mutation rewiring degron network	0.2778

Kaplan plot for FGD5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FGD5

UniProt ID: Q6ZNL6

Entrez ID: 152273

Protein name: FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FGD5 in