DegronMD

Uniprot ID: Q6ZNL6

Source protein: FYVE, RhoGEF and PH domain-containing protein 5

Source gene: FGD5

Class: LIG_APCC_ABBA_1

Location: 560:565

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8017

ASA_SCORE: 65.7

COIL: 0.5852

CONS_SCORE: 0.322

DSS_SCORE: 0.4694

HELIX: 0.0235

FCONS_SCORE: 0.8549

RIG_SCORE: 0.7497

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R575M	TCGA-19-5956	GBM	TCGA	VSVYQE	LIG_APCC_ABBA_1	0.0556
p.D572G	TCGA-A5-A0G2	UCEC	TCGA	VSVYQE	LIG_APCC_ABBA_1	0.1389
p.E557D	TCGA-AX-A06F	UCEC	TCGA	VSVYQE	LIG_APCC_ABBA_1	0.25
p.E557D	TCGA-EO-A22U	UCEC	TCGA	VSVYQE	LIG_APCC_ABBA_1	0.25
p.Q564K	TCGA-CV-7252	HNSC	TCGA	VSVYQE	LIG_APCC_ABBA_1	0.5833
p.Q564K	ACH-000901	Lung Cancer	CCLE	VSVYQE	LIG_APCC_ABBA_1	0.5833
p.H574N	TCGA-EE-A2M7	SKCM	TCGA	VSVYQE	LIG_APCC_ABBA_1	0.0833
p.E567Q	TCGA-UY-A78K	BLCA	TCGA	VSVYQE	LIG_APCC_ABBA_1	0.2778
p.E567K	TCGA-XX-A89A	BRCA	TCGA	VSVYQE	LIG_APCC_ABBA_1	0.2778
p.E575K	DO8898	COAD	ICGC	VSVYQE	LIG_APCC_ABBA_1	0.0556
p.E575K	DO220875	MELA	ICGC	VSVYQE	LIG_APCC_ABBA_1	0.0556
p.E575K	DO37433	SKCM	ICGC	VSVYQE	LIG_APCC_ABBA_1	0.0556
p.A556P	DO26425	LUSC	ICGC	VSVYQE	LIG_APCC_ABBA_1	0.2222
p.L570P	DO42033	UCEC	ICGC	VSVYQE	LIG_APCC_ABBA_1	0.1944
p.A554V	DO43186	UCEC	ICGC	VSVYQE	LIG_APCC_ABBA_1	0.1667
p.A554V	DO42608	UCEC	ICGC	VSVYQE	LIG_APCC_ABBA_1	0.1667
p.A554V	DO41235	UCEC	ICGC	VSVYQE	LIG_APCC_ABBA_1	0.1667
p.A558T	DO41871	UCEC	ICGC	VSVYQE	LIG_APCC_ABBA_1	0.2778
p.A558T	DO41235	UCEC	ICGC	VSVYQE	LIG_APCC_ABBA_1	0.2778
p.A558T	SW48	large_intestine	COSMIC	VSVYQE	LIG_APCC_ABBA_1	0.2778
p.A569T	DO42472	UCEC	ICGC	VSVYQE	LIG_APCC_ABBA_1	0.2222
p.P566T	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	VSVYQE	LIG_APCC_ABBA_1	0.3056
p.P566T	ACH-000843	Lung Cancer	CCLE	VSVYQE	LIG_APCC_ABBA_1	0.3056
p.P566T	HARA	lung	COSMIC	VSVYQE	LIG_APCC_ABBA_1	0.3056
p.P566R	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	VSVYQE	LIG_APCC_ABBA_1	0.3056
p.P566R	ACH-000843	Lung Cancer	CCLE	VSVYQE	LIG_APCC_ABBA_1	0.3056
p.P566R	HARA	lung	COSMIC	VSVYQE	LIG_APCC_ABBA_1	0.3056
p.V562M	SIDM00090	Ovarian Carcinoma	GDSC	VSVYQE	LIG_APCC_ABBA_1	0.6097
p.S550P	SIDM00217	Colorectal Carcinoma	GDSC	VSVYQE	LIG_APCC_ABBA_1	0.0556
p.S550P	ACH-000999	Colon/Colorectal Cancer	CCLE	VSVYQE	LIG_APCC_ABBA_1	0.0556
p.S550P	SNU-1040	large_intestine	COSMIC	VSVYQE	LIG_APCC_ABBA_1	0.0556
p.V560A	ACH-002926	Unknown	CCLE	VSVYQE	LIG_APCC_ABBA_1	0.6936
p.A558V	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	VSVYQE	LIG_APCC_ABBA_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSVYQE

Degron related mutations and impact score

Drug responses associated with FGD5 mutations

All proteins holding degron of VSVYQE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZNL6	FYVE, RhoGEF and PH domain-containing protein 5	LIG_APCC_ABBA_1	560:565	VSVYQE	APC,CDC20,FZR1	0.8017	More...