DegronMD

Uniprot ID: Q6ZNL6

Source protein: FYVE, RhoGEF and PH domain-containing protein 5

Source gene: FGD5

Class: LIG_APCC_ABBA_1

Location: 560:565

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8017

ASA_SCORE: 65.7

COIL: 0.5852

CONS_SCORE: 0.322

DSS_SCORE: 0.4694

HELIX: 0.0235

FCONS_SCORE: 0.8549

RIG_SCORE: 0.7497

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V560A	ACH-002926	Unknown	CCLE	VSVYQE	LIG_APCC_ABBA_1	0.6936
p.V562M	SIDM00090	Ovarian Carcinoma	GDSC	VSVYQE	LIG_APCC_ABBA_1	0.6097
p.Q564K	TCGA-CV-7252	HNSC	TCGA	VSVYQE	LIG_APCC_ABBA_1	0.5833
p.Q564K	ACH-000901	Lung Cancer	CCLE	VSVYQE	LIG_APCC_ABBA_1	0.5833
p.P566T	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	VSVYQE	LIG_APCC_ABBA_1	0.3056
p.P566T	ACH-000843	Lung Cancer	CCLE	VSVYQE	LIG_APCC_ABBA_1	0.3056
p.P566T	HARA	lung	COSMIC	VSVYQE	LIG_APCC_ABBA_1	0.3056
p.P566R	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	VSVYQE	LIG_APCC_ABBA_1	0.3056
p.P566R	ACH-000843	Lung Cancer	CCLE	VSVYQE	LIG_APCC_ABBA_1	0.3056
p.P566R	HARA	lung	COSMIC	VSVYQE	LIG_APCC_ABBA_1	0.3056
p.E567Q	TCGA-UY-A78K	BLCA	TCGA	VSVYQE	LIG_APCC_ABBA_1	0.2778
p.E567K	TCGA-XX-A89A	BRCA	TCGA	VSVYQE	LIG_APCC_ABBA_1	0.2778
p.A558T	DO41871	UCEC	ICGC	VSVYQE	LIG_APCC_ABBA_1	0.2778
p.A558T	DO41235	UCEC	ICGC	VSVYQE	LIG_APCC_ABBA_1	0.2778
p.A558T	SW48	large_intestine	COSMIC	VSVYQE	LIG_APCC_ABBA_1	0.2778
p.A558V	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	VSVYQE	LIG_APCC_ABBA_1	0.2778
p.E557D	TCGA-AX-A06F	UCEC	TCGA	VSVYQE	LIG_APCC_ABBA_1	0.25
p.E557D	TCGA-EO-A22U	UCEC	TCGA	VSVYQE	LIG_APCC_ABBA_1	0.25
p.A556P	DO26425	LUSC	ICGC	VSVYQE	LIG_APCC_ABBA_1	0.2222
p.A569T	DO42472	UCEC	ICGC	VSVYQE	LIG_APCC_ABBA_1	0.2222
p.L570P	DO42033	UCEC	ICGC	VSVYQE	LIG_APCC_ABBA_1	0.1944
p.A554V	DO43186	UCEC	ICGC	VSVYQE	LIG_APCC_ABBA_1	0.1667
p.A554V	DO42608	UCEC	ICGC	VSVYQE	LIG_APCC_ABBA_1	0.1667
p.A554V	DO41235	UCEC	ICGC	VSVYQE	LIG_APCC_ABBA_1	0.1667
p.D572G	TCGA-A5-A0G2	UCEC	TCGA	VSVYQE	LIG_APCC_ABBA_1	0.1389

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZNL6	FYVE, RhoGEF and PH domain-containing protein 5	LIG_APCC_ABBA_1	560:565	VSVYQE	APC,CDC20,FZR1	0.8017	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons