DegronMD - Q6ZR52(ZNF493)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q649H	TCGA-04-1360	OV	TCGA	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.1111
p.S641Y	TCGA-13-0800	OV	TCGA	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation altering degron motif	0.712
p.A645T	TCGA-21-5783	LUSC	TCGA	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.2222
p.A645T	SIDM00519	Mesothelioma	GDSC	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.2222
p.C634F	TCGA-55-7911	LUAD	TCGA	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.2778
p.K627N	TCGA-77-A5GH	LUSC	TCGA	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.0833
p.K627N	DO45452	LUSC	ICGC	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.0833
p.K627N	SIDM02059	Colorectal Carcinoma	GDSC	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.0833
p.S641P	TCGA-AP-A054	UCEC	TCGA	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation altering degron motif	0.6752
p.R640W	TCGA-AX-A2HD	UCEC	TCGA	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation altering degron motif	0.8634
p.R640W	TCGA-EX-A1H5	CESC	TCGA	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation altering degron motif	0.8634
p.K630R	TCGA-DU-6392	LGG	TCGA	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.1667
p.R640Q	TCGA-EO-A22R	UCEC	TCGA	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation altering degron motif	0.7329
p.H643D	TCGA-TT-A6YP	PCPG	TCGA	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.2778
p.H639D	DO48385	BLCA	ICGC	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation altering degron motif	0.7688
p.H639Y	DO773	BLCA	ICGC	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation altering degron motif	0.6118
p.S626L	DO773	BLCA	ICGC	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.0556
p.E641K	DO228295	BRCA	ICGC	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation altering degron motif	0.7022
p.K632T	DO219912	DLBC	ICGC	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation substituting flanking lysine	0.3333
p.K632T	DO43907	UCEC	ICGC	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation substituting flanking lysine	0.3333
p.E642G	DO52110	HNSC	ICGC	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.3056
p.R630S	DO26689	LUSC	ICGC	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.1667
p.I636T	DO27295	LUSC	ICGC	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation altering degron motif	0.7078
p.I633T	DO219191	LUSC	ICGC	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.25
p.I633V	DO27192	LUSC	ICGC	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.25
p.I633V	KYSE-410	oesophagus	COSMIC	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.25
p.S629N	DO222843	MELA	ICGC	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.1389
p.H635D	DO32666	OV	ICGC	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.3056
p.I633M	DO40884	UCEC	ICGC	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.25
p.K632N	DO41752	UCEC	ICGC	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation substituting flanking lysine	0.3333
p.P628L	SIDM00007	Other Solid Cancers	GDSC	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.1111
p.P628L	ACH-001550	Skin Cancer	CCLE	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.1111
p.P628L	MCC13	skin	COSMIC	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.1111
p.A637T	SIDM00837	Colorectal Carcinoma	GDSC	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation altering degron motif	0.7139
p.A637T	ACH-000958	Colon/Colorectal Cancer	CCLE	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation altering degron motif	0.7139
p.A637T	SW48	large intestine	COSMIC	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation altering degron motif	0.7139
p.K648N	SIDM01318	Hepatocellular Carcinoma	GDSC	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.1389
p.K648N	ACH-001318	Liver Cancer	CCLE	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.1389
p.E633A	ACH-000455	Brain Cancer	CCLE	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.25
p.H651N	ACH-001322	Sarcoma	CCLE	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.0556
p.E633K	ACH-002190	Kidney Cancer	CCLE	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.25
p.E633K	ACH-002215	Lymphoma	CCLE	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.25
p.E633K	RCC-JF	kidney	COSMIC	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.25
p.E633K	BC-3	haematopoietic and lymphoid tissue	COSMIC	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.25
p.H635R	EHEB	haematopoietic and lymphoid tissue	COSMIC	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.3056
p.R630I	NCI-H2172	lung	COSMIC	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.1667
p.H631L	JHU-029	upper aerodigestive tract	COSMIC	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.1944
p.H627R	NCI-H1688	lung	COSMIC	IGIHTE	LIG_APCC_ABBA_1	636:641	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF493

UniProt ID: Q6ZR52

Entrez ID: 284443

Protein name: Zinc finger protein 493

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF493 in