DegronMD

Uniprot ID: Q6ZR52

Source protein: Zinc finger protein 493

Source gene: ZNF493

Class: LIG_APCC_ABBA_1

Location: 636:641

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9968

ASA_SCORE: 77.5333

COIL: 0.8197

CONS_SCORE: 0.175

DSS_SCORE: 0.5434

HELIX: 0.0395

FCONS_SCORE: 0.7457

RIG_SCORE: 0.7597

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q649H	TCGA-04-1360	OV	TCGA	IGIHTE	LIG_APCC_ABBA_1	0.1111
p.S641Y	TCGA-13-0800	OV	TCGA	IGIHTE	LIG_APCC_ABBA_1	0.712
p.A645T	TCGA-21-5783	LUSC	TCGA	IGIHTE	LIG_APCC_ABBA_1	0.2222
p.A645T	SIDM00519	Mesothelioma	GDSC	IGIHTE	LIG_APCC_ABBA_1	0.2222
p.C634F	TCGA-55-7911	LUAD	TCGA	IGIHTE	LIG_APCC_ABBA_1	0.2778
p.K627N	TCGA-77-A5GH	LUSC	TCGA	IGIHTE	LIG_APCC_ABBA_1	0.0833
p.K627N	DO45452	LUSC	ICGC	IGIHTE	LIG_APCC_ABBA_1	0.0833
p.K627N	SIDM02059	Colorectal Carcinoma	GDSC	IGIHTE	LIG_APCC_ABBA_1	0.0833
p.S641P	TCGA-AP-A054	UCEC	TCGA	IGIHTE	LIG_APCC_ABBA_1	0.6752
p.R640W	TCGA-AX-A2HD	UCEC	TCGA	IGIHTE	LIG_APCC_ABBA_1	0.8634
p.R640W	TCGA-EX-A1H5	CESC	TCGA	IGIHTE	LIG_APCC_ABBA_1	0.8634
p.K630R	TCGA-DU-6392	LGG	TCGA	IGIHTE	LIG_APCC_ABBA_1	0.1667
p.R640Q	TCGA-EO-A22R	UCEC	TCGA	IGIHTE	LIG_APCC_ABBA_1	0.7329
p.H643D	TCGA-TT-A6YP	PCPG	TCGA	IGIHTE	LIG_APCC_ABBA_1	0.2778
p.H639D	DO48385	BLCA	ICGC	IGIHTE	LIG_APCC_ABBA_1	0.7688
p.H639Y	DO773	BLCA	ICGC	IGIHTE	LIG_APCC_ABBA_1	0.6118
p.S626L	DO773	BLCA	ICGC	IGIHTE	LIG_APCC_ABBA_1	0.0556
p.E641K	DO228295	BRCA	ICGC	IGIHTE	LIG_APCC_ABBA_1	0.7022
p.K632T	DO219912	DLBC	ICGC	IGIHTE	LIG_APCC_ABBA_1	0.3333
p.K632T	DO43907	UCEC	ICGC	IGIHTE	LIG_APCC_ABBA_1	0.3333
p.E642G	DO52110	HNSC	ICGC	IGIHTE	LIG_APCC_ABBA_1	0.3056
p.R630S	DO26689	LUSC	ICGC	IGIHTE	LIG_APCC_ABBA_1	0.1667
p.I636T	DO27295	LUSC	ICGC	IGIHTE	LIG_APCC_ABBA_1	0.7078
p.I633T	DO219191	LUSC	ICGC	IGIHTE	LIG_APCC_ABBA_1	0.25
p.I633V	DO27192	LUSC	ICGC	IGIHTE	LIG_APCC_ABBA_1	0.25
p.I633V	KYSE-410	oesophagus	COSMIC	IGIHTE	LIG_APCC_ABBA_1	0.25
p.S629N	DO222843	MELA	ICGC	IGIHTE	LIG_APCC_ABBA_1	0.1389
p.H635D	DO32666	OV	ICGC	IGIHTE	LIG_APCC_ABBA_1	0.3056
p.I633M	DO40884	UCEC	ICGC	IGIHTE	LIG_APCC_ABBA_1	0.25
p.K632N	DO41752	UCEC	ICGC	IGIHTE	LIG_APCC_ABBA_1	0.3333
p.P628L	SIDM00007	Other Solid Cancers	GDSC	IGIHTE	LIG_APCC_ABBA_1	0.1111
p.P628L	ACH-001550	Skin Cancer	CCLE	IGIHTE	LIG_APCC_ABBA_1	0.1111
p.P628L	MCC13	skin	COSMIC	IGIHTE	LIG_APCC_ABBA_1	0.1111
p.A637T	SIDM00837	Colorectal Carcinoma	GDSC	IGIHTE	LIG_APCC_ABBA_1	0.7139
p.A637T	ACH-000958	Colon/Colorectal Cancer	CCLE	IGIHTE	LIG_APCC_ABBA_1	0.7139
p.A637T	SW48	large_intestine	COSMIC	IGIHTE	LIG_APCC_ABBA_1	0.7139
p.K648N	SIDM01318	Hepatocellular Carcinoma	GDSC	IGIHTE	LIG_APCC_ABBA_1	0.1389
p.K648N	ACH-001318	Liver Cancer	CCLE	IGIHTE	LIG_APCC_ABBA_1	0.1389
p.E633A	ACH-000455	Brain Cancer	CCLE	IGIHTE	LIG_APCC_ABBA_1	0.25
p.H651N	ACH-001322	Sarcoma	CCLE	IGIHTE	LIG_APCC_ABBA_1	0.0556
p.E633K	ACH-002190	Kidney Cancer	CCLE	IGIHTE	LIG_APCC_ABBA_1	0.25
p.E633K	ACH-002215	Lymphoma	CCLE	IGIHTE	LIG_APCC_ABBA_1	0.25
p.E633K	RCC-JF	kidney	COSMIC	IGIHTE	LIG_APCC_ABBA_1	0.25
p.E633K	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	IGIHTE	LIG_APCC_ABBA_1	0.25
p.H635R	EHEB	haematopoietic_and_lymphoid_tissue	COSMIC	IGIHTE	LIG_APCC_ABBA_1	0.3056
p.R630I	NCI-H2172	lung	COSMIC	IGIHTE	LIG_APCC_ABBA_1	0.1667
p.H631L	JHU-029	upper_aerodigestive_tract	COSMIC	IGIHTE	LIG_APCC_ABBA_1	0.1944
p.H627R	NCI-H1688	lung	COSMIC	IGIHTE	LIG_APCC_ABBA_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IGIHTE

Degron related mutations and impact score

Drug responses associated with ZNF493 mutations

All proteins holding degron of IGIHTE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZR52	Zinc finger protein 493	LIG_APCC_ABBA_1	636:641	IGIHTE	APC,CDC20,FZR1	0.9968	More...