DegronMD

Uniprot ID: Q6ZR52

Source protein: Zinc finger protein 493

Source gene: ZNF493

Class: LIG_APCC_ABBA_1

Location: 636:641

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9968

ASA_SCORE: 77.5333

COIL: 0.8197

CONS_SCORE: 0.175

DSS_SCORE: 0.5434

HELIX: 0.0395

FCONS_SCORE: 0.7457

RIG_SCORE: 0.7597

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R640W	TCGA-AX-A2HD	UCEC	TCGA	IGIHTE	LIG_APCC_ABBA_1	0.8634
p.R640W	TCGA-EX-A1H5	CESC	TCGA	IGIHTE	LIG_APCC_ABBA_1	0.8634
p.H639D	DO48385	BLCA	ICGC	IGIHTE	LIG_APCC_ABBA_1	0.7688
p.R640Q	TCGA-EO-A22R	UCEC	TCGA	IGIHTE	LIG_APCC_ABBA_1	0.7329
p.A637T	SIDM00837	Colorectal Carcinoma	GDSC	IGIHTE	LIG_APCC_ABBA_1	0.7139
p.A637T	ACH-000958	Colon/Colorectal Cancer	CCLE	IGIHTE	LIG_APCC_ABBA_1	0.7139
p.A637T	SW48	large_intestine	COSMIC	IGIHTE	LIG_APCC_ABBA_1	0.7139
p.S641Y	TCGA-13-0800	OV	TCGA	IGIHTE	LIG_APCC_ABBA_1	0.712
p.I636T	DO27295	LUSC	ICGC	IGIHTE	LIG_APCC_ABBA_1	0.7078
p.E641K	DO228295	BRCA	ICGC	IGIHTE	LIG_APCC_ABBA_1	0.7022
p.S641P	TCGA-AP-A054	UCEC	TCGA	IGIHTE	LIG_APCC_ABBA_1	0.6752
p.H639Y	DO773	BLCA	ICGC	IGIHTE	LIG_APCC_ABBA_1	0.6118
p.K632T	DO219912	DLBC	ICGC	IGIHTE	LIG_APCC_ABBA_1	0.3333
p.K632T	DO43907	UCEC	ICGC	IGIHTE	LIG_APCC_ABBA_1	0.3333
p.K632N	DO41752	UCEC	ICGC	IGIHTE	LIG_APCC_ABBA_1	0.3333
p.E642G	DO52110	HNSC	ICGC	IGIHTE	LIG_APCC_ABBA_1	0.3056
p.H635D	DO32666	OV	ICGC	IGIHTE	LIG_APCC_ABBA_1	0.3056
p.H635R	EHEB	haematopoietic_and_lymphoid_tissue	COSMIC	IGIHTE	LIG_APCC_ABBA_1	0.3056
p.C634F	TCGA-55-7911	LUAD	TCGA	IGIHTE	LIG_APCC_ABBA_1	0.2778
p.H643D	TCGA-TT-A6YP	PCPG	TCGA	IGIHTE	LIG_APCC_ABBA_1	0.2778
p.I633T	DO219191	LUSC	ICGC	IGIHTE	LIG_APCC_ABBA_1	0.25
p.I633V	DO27192	LUSC	ICGC	IGIHTE	LIG_APCC_ABBA_1	0.25
p.I633V	KYSE-410	oesophagus	COSMIC	IGIHTE	LIG_APCC_ABBA_1	0.25
p.I633M	DO40884	UCEC	ICGC	IGIHTE	LIG_APCC_ABBA_1	0.25
p.E633A	ACH-000455	Brain Cancer	CCLE	IGIHTE	LIG_APCC_ABBA_1	0.25

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZR52	Zinc finger protein 493	LIG_APCC_ABBA_1	636:641	IGIHTE	APC,CDC20,FZR1	0.9968	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons