DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
LRRC9
UniProt ID:
Q6ZRR7
Entrez ID:
Protein name:
Leucine-rich repeat-containing protein 9
External links:
UniprotKB
HGNC
RefSeq
COSMIC
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HERE
for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
cytoplasm [GO:0005737]...
cytoplasm [GO:0005737]
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
LRRC9
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.F1391V
TCGA-E6-A1M0
UCEC
TCGA
VKTPPIE
DEG_SCF_FBW7_2
1394:1400
Mutation rewiring degron network
0.25
p.F1391V
DO43682
UCEC
ICGC
VKTPPIE
DEG_SCF_FBW7_2
1394:1400
Mutation rewiring degron network
0.25
p.E1400K
DO229346
LAML
ICGC
VKTPPIE
DEG_SCF_FBW7_2
1394:1400
Mutation altering degron motif
0.7022
p.E1400K
DO229480
LAML
ICGC
VKTPPIE
DEG_SCF_FBW7_2
1394:1400
Mutation altering degron motif
0.7022
p.G1392V
DO229019
LICA
ICGC
VKTPPIE
DEG_SCF_FBW7_2
1394:1400
Mutation rewiring degron network
0.2778
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for LRRC9 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc