DegronMD

Uniprot ID: Q6ZRR7

Source protein: Leucine-rich repeat-containing protein 9

Source gene: LRRC9

Class: DEG_SCF_FBW7_2

Location: 1394:1400

E3 ligase: FBXW7

DEGRON score: 0.5974

ASA_SCORE: 57.8

COIL: 0.5867

CONS_SCORE: 0.2621

DSS_SCORE: 0.3611

HELIX: 0.0184

FCONS_SCORE: 1.1036

RIG_SCORE: 0.7652

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F1391V	TCGA-E6-A1M0	UCEC	TCGA	VKTPPIE	DEG_SCF_FBW7_2	0.25
p.F1391V	DO43682	UCEC	ICGC	VKTPPIE	DEG_SCF_FBW7_2	0.25
p.E1400K	DO229346	LAML	ICGC	VKTPPIE	DEG_SCF_FBW7_2	0.7022
p.E1400K	DO229480	LAML	ICGC	VKTPPIE	DEG_SCF_FBW7_2	0.7022
p.G1392V	DO229019	LICA	ICGC	VKTPPIE	DEG_SCF_FBW7_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZRR7	Leucine-rich repeat-containing protein 9	DEG_SCF_FBW7_2	1394:1400	VKTPPIE	FBXW7	0.5974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons