DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
FAM43B
UniProt ID:
Q6ZT52
Entrez ID:
163933
Protein name:
Protein FAM43B
External links:
UniprotKB
HGNC
RefSeq
COSMIC
Please click
HERE
for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
...
View more >>
GO - Biological processes (BP):
...
View more >>
GO - Molecular function (MF):
...
View more >>
GO - Cellular component (CC):
...
View more >>
Choose a PDB ID:
Open in full screen with detailed sequence annotations
FAM43B
Control panel
Show dataset:
All datasets
TCGA
ICGC
COSMIC
CCLE
GDSC
Show Degron:
All sites
Degron
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Add PTM sites
Phosphorylation
Legend: PTM sites
Data table is loading....
AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.R237C
SIDM02071
Esophageal Carcinoma
GDSC
PRAPLRRLL
DEG_APCC_DBOX_1
232:240
Mutation altering degron motif
0.719
p.R233H
ACH-001061
Colon/Colorectal Cancer
CCLE
PRAPLRRLL
DEG_APCC_DBOX_1
232:240
Mutation altering degron motif
0.8244
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for FAM43B in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc