DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PRAPLRRLL
Uniprot ID:
Q6ZT52
Source protein:
Protein FAM43B
Source gene:
FAM43B
Class:
DEG_APCC_DBOX_1
Location:
232:240
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6607
ASA_SCORE:
96.9333
COIL:
0.579
CONS_SCORE:
0.7684
DSS_SCORE:
0.4566
HELIX:
0.365
FCONS_SCORE:
1.1179
RIG_SCORE:
0.746
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R237C
SIDM02071
Esophageal Carcinoma
GDSC
PRAPLRRLL
DEG_APCC_DBOX_1
0.719
p.R233H
ACH-001061
Colon/Colorectal Cancer
CCLE
PRAPLRRLL
DEG_APCC_DBOX_1
0.8244
Drug responses associated with FAM43B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PRAPLRRLL
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6ZT52
Protein FAM43B
DEG_APCC_DBOX_1
232:240
PRAPLRRLL
APC,CDC20,FZR1
0.6607
More...