DegronMD - Q6ZUM4(ARHGAP27)

ARHGAP27

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P438L	TCGA-AJ-A3IA	UCEC	TCGA	VRWELPQVP	DEG_APCC_DBOX_1	437:445	Mutation altering degron motif	0.7582
p.P438L	DO43082	UCEC	ICGC	VRWELPQVP	DEG_APCC_DBOX_1	437:445	Mutation altering degron motif	0.7582
p.S445P	TCGA-BH-A0RX	BRCA	TCGA	VRWELPQVP	DEG_APCC_DBOX_1	437:445	Mutation altering degron motif	0.6752
p.S445P	DO4866	BRCA	ICGC	VRWELPQVP	DEG_APCC_DBOX_1	437:445	Mutation altering degron motif	0.6752
p.E439K	TCGA-EI-6882	READ	TCGA	VRWELPQVP	DEG_APCC_DBOX_1	437:445	Mutation altering degron motif	0.7022
p.E439K	DO36531	READ	ICGC	VRWELPQVP	DEG_APCC_DBOX_1	437:445	Mutation altering degron motif	0.7022
p.S445L	TCGA-T2-A6WZ	HNSC	TCGA	VRWELPQVP	DEG_APCC_DBOX_1	437:445	Mutation altering degron motif	0.7667
p.S445L	DO219067	HNSC	ICGC	VRWELPQVP	DEG_APCC_DBOX_1	437:445	Mutation altering degron motif	0.7667
p.S451N	SIDM00151	Ovarian Carcinoma	GDSC	VRWELPQVP	DEG_APCC_DBOX_1	437:445	Mutation blocking phosphorylation signal	0.6111
p.S451N	ACH-000966	Ovarian Cancer	CCLE	VRWELPQVP	DEG_APCC_DBOX_1	437:445	Mutation blocking phosphorylation signal	0.6111
p.S451N	IGROV-1	ovary	COSMIC	VRWELPQVP	DEG_APCC_DBOX_1	437:445	Mutation blocking phosphorylation signal	0.6111
p.P443L	SCC-15	upper aerodigestive tract	COSMIC	VRWELPQVP	DEG_APCC_DBOX_1	437:445	Mutation altering degron motif	0.7582
p.K431T	G-MEL	skin	COSMIC	VRWELPQVP	DEG_APCC_DBOX_1	437:445	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc