DegronMD

Uniprot ID: Q6ZUM4

Source protein: Rho GTPase-activating protein 27

Source gene: ARHGAP27

Class: DEG_APCC_DBOX_1

Location: 437:445

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8693

ASA_SCORE: 88.6556

COIL: 0.7172

CONS_SCORE: 0.3837

DSS_SCORE: 0.5058

HELIX: 0.0313

FCONS_SCORE: 1.0231

RIG_SCORE: 0.7322

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P438L	TCGA-AJ-A3IA	UCEC	TCGA	VRWELPQVP	DEG_APCC_DBOX_1	0.7582
p.P438L	DO43082	UCEC	ICGC	VRWELPQVP	DEG_APCC_DBOX_1	0.7582
p.S445P	TCGA-BH-A0RX	BRCA	TCGA	VRWELPQVP	DEG_APCC_DBOX_1	0.6752
p.S445P	DO4866	BRCA	ICGC	VRWELPQVP	DEG_APCC_DBOX_1	0.6752
p.E439K	TCGA-EI-6882	READ	TCGA	VRWELPQVP	DEG_APCC_DBOX_1	0.7022
p.E439K	DO36531	READ	ICGC	VRWELPQVP	DEG_APCC_DBOX_1	0.7022
p.S445L	TCGA-T2-A6WZ	HNSC	TCGA	VRWELPQVP	DEG_APCC_DBOX_1	0.7667
p.S445L	DO219067	HNSC	ICGC	VRWELPQVP	DEG_APCC_DBOX_1	0.7667
p.S451N	SIDM00151	Ovarian Carcinoma	GDSC	VRWELPQVP	DEG_APCC_DBOX_1	0.6111
p.S451N	ACH-000966	Ovarian Cancer	CCLE	VRWELPQVP	DEG_APCC_DBOX_1	0.6111
p.S451N	IGROV-1	ovary	COSMIC	VRWELPQVP	DEG_APCC_DBOX_1	0.6111
p.P443L	SCC-15	upper_aerodigestive_tract	COSMIC	VRWELPQVP	DEG_APCC_DBOX_1	0.7582
p.K431T	G-MEL	skin	COSMIC	VRWELPQVP	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZUM4	Rho GTPase-activating protein 27	DEG_APCC_DBOX_1	437:445	VRWELPQVP	APC,CDC20,FZR1	0.8693	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons