DegronMD - Q6ZV73(FGD6)

FGD6

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L541I	TCGA-09-2044	OV	TCGA	ERNHLQHLC	DEG_APCC_DBOX_1	537:545	Mutation altering degron motif	0.7174
p.L541I	DO28923	OV	ICGC	ERNHLQHLC	DEG_APCC_DBOX_1	537:545	Mutation altering degron motif	0.7174
p.S531T	TCGA-21-1080	LUSC	TCGA	ERNHLQHLC	DEG_APCC_DBOX_1	537:545	Mutation rewiring degron network	0.1667
p.S531T	DO26502	LUSC	ICGC	ERNHLQHLC	DEG_APCC_DBOX_1	537:545	Mutation rewiring degron network	0.1667
p.R538T	TCGA-56-A5DS	LUSC	TCGA	ERNHLQHLC	DEG_APCC_DBOX_1	537:545	Mutation altering degron motif	0.7876
p.R538T	DO45494	LUSC	ICGC	ERNHLQHLC	DEG_APCC_DBOX_1	537:545	Mutation altering degron motif	0.7876
p.R549H	TCGA-MN-A4N4	LUAD	TCGA	ERNHLQHLC	DEG_APCC_DBOX_1	537:545	Mutation rewiring degron network	0.2222
p.R549H	DO26250	LUAD	ICGC	ERNHLQHLC	DEG_APCC_DBOX_1	537:545	Mutation rewiring degron network	0.2222
p.V551M	SIDM00156	Neuroblastoma	GDSC	ERNHLQHLC	DEG_APCC_DBOX_1	537:545	Mutation rewiring degron network	0.1667
p.V551M	NB7	autonomic ganglia	COSMIC	ERNHLQHLC	DEG_APCC_DBOX_1	537:545	Mutation rewiring degron network	0.1667
p.Q542H	SIDM00214	Colorectal Carcinoma	GDSC	ERNHLQHLC	DEG_APCC_DBOX_1	537:545	Mutation altering degron motif	0.647
p.Q542H	ACH-000955	Colon/Colorectal Cancer	CCLE	ERNHLQHLC	DEG_APCC_DBOX_1	537:545	Mutation altering degron motif	0.647
p.Q542H	SNU-407	large intestine	COSMIC	ERNHLQHLC	DEG_APCC_DBOX_1	537:545	Mutation altering degron motif	0.647

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*NOTE: the Kaplan plots were collected from OncoLnc