DegronMD

Uniprot ID: Q6ZV73

Source protein: FYVE, RhoGEF and PH domain-containing protein 6

Source gene: FGD6

Class: DEG_APCC_DBOX_1

Location: 537:545

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9598

ASA_SCORE: 105.1778

COIL: 0.4462

CONS_SCORE: 0.2551

DSS_SCORE: 0.5693

HELIX: 0.5186

FCONS_SCORE: 0.9914

RIG_SCORE: 0.712

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L541I	TCGA-09-2044	OV	TCGA	ERNHLQHLC	DEG_APCC_DBOX_1	0.7174
p.L541I	DO28923	OV	ICGC	ERNHLQHLC	DEG_APCC_DBOX_1	0.7174
p.S531T	TCGA-21-1080	LUSC	TCGA	ERNHLQHLC	DEG_APCC_DBOX_1	0.1667
p.S531T	DO26502	LUSC	ICGC	ERNHLQHLC	DEG_APCC_DBOX_1	0.1667
p.R538T	TCGA-56-A5DS	LUSC	TCGA	ERNHLQHLC	DEG_APCC_DBOX_1	0.7876
p.R538T	DO45494	LUSC	ICGC	ERNHLQHLC	DEG_APCC_DBOX_1	0.7876
p.R549H	TCGA-MN-A4N4	LUAD	TCGA	ERNHLQHLC	DEG_APCC_DBOX_1	0.2222
p.R549H	DO26250	LUAD	ICGC	ERNHLQHLC	DEG_APCC_DBOX_1	0.2222
p.V551M	SIDM00156	Neuroblastoma	GDSC	ERNHLQHLC	DEG_APCC_DBOX_1	0.1667
p.V551M	NB7	autonomic_ganglia	COSMIC	ERNHLQHLC	DEG_APCC_DBOX_1	0.1667
p.Q542H	SIDM00214	Colorectal Carcinoma	GDSC	ERNHLQHLC	DEG_APCC_DBOX_1	0.647
p.Q542H	ACH-000955	Colon/Colorectal Cancer	CCLE	ERNHLQHLC	DEG_APCC_DBOX_1	0.647
p.Q542H	SNU-407	large_intestine	COSMIC	ERNHLQHLC	DEG_APCC_DBOX_1	0.647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZV73	FYVE, RhoGEF and PH domain-containing protein 6	DEG_APCC_DBOX_1	537:545	ERNHLQHLC	APC,CDC20,FZR1	0.9598	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons