DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
LINC02908
UniProt ID:
Q6ZV77
Entrez ID:
401563
Protein name:
Putative uncharacterized protein LINC02908 (Long intergenic non-protein coding RNA 2908)
External links:
UniprotKB
HGNC
RefSeq
COSMIC
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for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
LINC02908
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TCGA
ICGC
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CCLE
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Show Degron:
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Phosphorylation
Legend: PTM sites
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.R71C
TCGA-32-2491
GBM
TCGA
MQTPGGS
DEG_SCF_FBW7_1
55:61
Mutation rewiring degron network
0.0556
p.R71C
DO13354
GBM
ICGC
MQTPGGS
DEG_SCF_FBW7_1
55:61
Mutation rewiring degron network
0.0556
p.S61R
TCGA-33-AASJ
LUSC
TCGA
MQTPGGS
DEG_SCF_FBW7_1
55:61
Mutation altering degron motif
0.8538
p.S61R
DO219131
LUSC
ICGC
MQTPGGS
DEG_SCF_FBW7_1
55:61
Mutation altering degron motif
0.8538
p.E66D
TCGA-AJ-A3IA
UCEC
TCGA
MQTPGGS
DEG_SCF_FBW7_1
55:61
Mutation rewiring degron network
0.1944
p.E66D
DO43082
UCEC
ICGC
MQTPGGS
DEG_SCF_FBW7_1
55:61
Mutation rewiring degron network
0.1944
p.A67D
TCGA-AX-A1CE
UCEC
TCGA
MQTPGGS
DEG_SCF_FBW7_1
55:61
Mutation rewiring degron network
0.1667
p.A67D
DO42280
UCEC
ICGC
MQTPGGS
DEG_SCF_FBW7_1
55:61
Mutation rewiring degron network
0.1667
p.R64K
TCGA-CG-5723
STAD
TCGA
MQTPGGS
DEG_SCF_FBW7_1
55:61
Mutation rewiring degron network
0.25
p.R64K
DO38376
STAD
ICGC
MQTPGGS
DEG_SCF_FBW7_1
55:61
Mutation rewiring degron network
0.25
p.L51M
TCGA-FS-A1ZN
SKCM
TCGA
MQTPGGS
DEG_SCF_FBW7_1
55:61
Mutation rewiring degron network
0.2222
p.L51M
DO38165
SKCM
ICGC
MQTPGGS
DEG_SCF_FBW7_1
55:61
Mutation rewiring degron network
0.2222
p.R71S
TCGA-V1-A8WV
PRAD
TCGA
MQTPGGS
DEG_SCF_FBW7_1
55:61
Mutation rewiring degron network
0.0556
p.R71S
DO219363
PRAD
ICGC
MQTPGGS
DEG_SCF_FBW7_1
55:61
Mutation rewiring degron network
0.0556
p.D49A
DO222794
COCA
ICGC
MQTPGGS
DEG_SCF_FBW7_1
55:61
Mutation rewiring degron network
0.1667
p.S62T
DO234153
ESAD
ICGC
MQTPGGS
DEG_SCF_FBW7_1
55:61
Mutation blocking phosphorylation signal
0.75
p.S61I
DO229025
LICA
ICGC
MQTPGGS
DEG_SCF_FBW7_1
55:61
Mutation altering degron motif
0.8453
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for LINC02908 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc