DegronMD

Uniprot ID: Q6ZV77

Source protein: Putative uncharacterized protein LINC02908

Source gene: LINC02908

Class: DEG_SCF_FBW7_1

Location: 55:61

E3 ligase: FBXW7

DEGRON score: 0.9893

ASA_SCORE: 61.7571

COIL: 0.7199

CONS_SCORE: 0

DSS_SCORE: 0.4444

HELIX: 0.0563

FCONS_SCORE: 0

RIG_SCORE: 0.6406

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R71C	TCGA-32-2491	GBM	TCGA	MQTPGGS	DEG_SCF_FBW7_1	0.0556
p.R71C	DO13354	GBM	ICGC	MQTPGGS	DEG_SCF_FBW7_1	0.0556
p.S61R	TCGA-33-AASJ	LUSC	TCGA	MQTPGGS	DEG_SCF_FBW7_1	0.8538
p.S61R	DO219131	LUSC	ICGC	MQTPGGS	DEG_SCF_FBW7_1	0.8538
p.E66D	TCGA-AJ-A3IA	UCEC	TCGA	MQTPGGS	DEG_SCF_FBW7_1	0.1944
p.E66D	DO43082	UCEC	ICGC	MQTPGGS	DEG_SCF_FBW7_1	0.1944
p.A67D	TCGA-AX-A1CE	UCEC	TCGA	MQTPGGS	DEG_SCF_FBW7_1	0.1667
p.A67D	DO42280	UCEC	ICGC	MQTPGGS	DEG_SCF_FBW7_1	0.1667
p.R64K	TCGA-CG-5723	STAD	TCGA	MQTPGGS	DEG_SCF_FBW7_1	0.25
p.R64K	DO38376	STAD	ICGC	MQTPGGS	DEG_SCF_FBW7_1	0.25
p.L51M	TCGA-FS-A1ZN	SKCM	TCGA	MQTPGGS	DEG_SCF_FBW7_1	0.2222
p.L51M	DO38165	SKCM	ICGC	MQTPGGS	DEG_SCF_FBW7_1	0.2222
p.R71S	TCGA-V1-A8WV	PRAD	TCGA	MQTPGGS	DEG_SCF_FBW7_1	0.0556
p.R71S	DO219363	PRAD	ICGC	MQTPGGS	DEG_SCF_FBW7_1	0.0556
p.D49A	DO222794	COCA	ICGC	MQTPGGS	DEG_SCF_FBW7_1	0.1667
p.S62T	DO234153	ESAD	ICGC	MQTPGGS	DEG_SCF_FBW7_1	0.75
p.S61I	DO229025	LICA	ICGC	MQTPGGS	DEG_SCF_FBW7_1	0.8453

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZV77	Putative uncharacterized protein LINC02908	DEG_SCF_FBW7_1	55:61	MQTPGGS	FBXW7	0.9893	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons