DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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LINC02898
UniProt ID:
Q6ZV80
Entrez ID:
Protein name:
Putative uncharacterized protein LINC02898 (Long intergenic non-protein coding RNA 2898)
External links:
UniprotKB
HGNC
RefSeq
COSMIC
Please click
HERE
for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
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Open in full screen with detailed sequence annotations
LINC02898
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.N69K
DO229035
LICA
ICGC
GRHTLSQVP
DEG_APCC_DBOX_1
60:68
Mutation rewiring degron network
0.3056
p.P68L
DO220906
MELA
ICGC
GRHTLSQVP
DEG_APCC_DBOX_1
60:68
Mutation altering degron motif
0.6471
p.R59G
DO229208
THCA
ICGC
GRHTLSQVP
DEG_APCC_DBOX_1
60:68
Mutation rewiring degron network
0.3056
p.P54S
SIDM00375
Head and Neck Carcinoma
GDSC
GRHTLSQVP
DEG_APCC_DBOX_1
60:68
Mutation rewiring degron network
0.1667
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for LINC02898 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc