DegronMD - Q70J99(UNC13D)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F47L	TCGA-BH-A0DG	BRCA	TCGA	RALLYED	LIG_APCC_ABBAyCdc20_2	52:58	Mutation rewiring degron network	0.1944
p.F47L	DO1257	BRCA	ICGC	RALLYED	LIG_APCC_ABBAyCdc20_2	52:58	Mutation rewiring degron network	0.1944
p.R52Q	TCGA-D1-A15X	UCEC	TCGA	RALLYED	LIG_APCC_ABBAyCdc20_2	52:58	Mutation altering degron motif	0.7329
p.R52Q	DO43274	UCEC	ICGC	RALLYED	LIG_APCC_ABBAyCdc20_2	52:58	Mutation altering degron motif	0.7329
p.R52L	TCGA-DZ-6131	KIRP	TCGA	RALLYED	LIG_APCC_ABBAyCdc20_2	52:58	Mutation altering degron motif	0.8428
p.R52L	DO20911	KIRP	ICGC	RALLYED	LIG_APCC_ABBAyCdc20_2	52:58	Mutation altering degron motif	0.8428
p.P43L	TCGA-PK-A5HB	ACC	TCGA	RALLYED	LIG_APCC_ABBAyCdc20_2	52:58	Mutation rewiring degron network	0.0833
p.A59T	DO222755	COCA	ICGC	RALLYED	LIG_APCC_ABBAyCdc20_2	52:58	Mutation rewiring degron network	0.3056
p.H45N	DO51087	PRAD	ICGC	RALLYED	LIG_APCC_ABBAyCdc20_2	52:58	Mutation rewiring degron network	0.1389
p.R66H	DO41199	UCEC	ICGC	RALLYED	LIG_APCC_ABBAyCdc20_2	52:58	Mutation rewiring degron network	0.1111
p.R66H	SIDM01693	B-Lymphoblastic Leukemia	GDSC	RALLYED	LIG_APCC_ABBAyCdc20_2	52:58	Mutation rewiring degron network	0.1111
p.R66H	ACH-000032	Leukemia	CCLE	RALLYED	LIG_APCC_ABBAyCdc20_2	52:58	Mutation rewiring degron network	0.1111
p.R66H	ACH-001616	Lymphoma	CCLE	RALLYED	LIG_APCC_ABBAyCdc20_2	52:58	Mutation rewiring degron network	0.1111
p.E50K	SIDM01609	Endometrial Carcinoma	GDSC	RALLYED	LIG_APCC_ABBAyCdc20_2	52:58	Mutation rewiring degron network	0.2778
p.E50K	ACH-000972	Endometrial/Uterine Cancer	CCLE	RALLYED	LIG_APCC_ABBAyCdc20_2	52:58	Mutation rewiring degron network	0.2778
p.L60F	SIDM01612	Endometrial Carcinoma	GDSC	RALLYED	LIG_APCC_ABBAyCdc20_2	52:58	Mutation rewiring degron network	0.2778
p.L60F	ACH-000946	Endometrial/Uterine Cancer	CCLE	RALLYED	LIG_APCC_ABBAyCdc20_2	52:58	Mutation rewiring degron network	0.2778

Kaplan plot for UNC13D in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UNC13D

UniProt ID: Q70J99

Entrez ID: 201294

Protein name: Protein unc-13 homolog D (Munc13-4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UNC13D in