DegronMD

Uniprot ID: Q70J99

Source protein: Protein unc-13 homolog D

Source gene: UNC13D

Class: LIG_APCC_ABBAyCdc20_2

Location: 52:58

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7868

ASA_SCORE: 31.4143

COIL: 0.0037

CONS_SCORE: 0.3842

DSS_SCORE: 0.3546

HELIX: 0.9949

FCONS_SCORE: 1.0763

RIG_SCORE: 0.7695

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F47L	TCGA-BH-A0DG	BRCA	TCGA	RALLYED	LIG_APCC_ABBAyCdc20_2	0.1944
p.F47L	DO1257	BRCA	ICGC	RALLYED	LIG_APCC_ABBAyCdc20_2	0.1944
p.R52Q	TCGA-D1-A15X	UCEC	TCGA	RALLYED	LIG_APCC_ABBAyCdc20_2	0.7329
p.R52Q	DO43274	UCEC	ICGC	RALLYED	LIG_APCC_ABBAyCdc20_2	0.7329
p.R52L	TCGA-DZ-6131	KIRP	TCGA	RALLYED	LIG_APCC_ABBAyCdc20_2	0.8428
p.R52L	DO20911	KIRP	ICGC	RALLYED	LIG_APCC_ABBAyCdc20_2	0.8428
p.P43L	TCGA-PK-A5HB	ACC	TCGA	RALLYED	LIG_APCC_ABBAyCdc20_2	0.0833
p.A59T	DO222755	COCA	ICGC	RALLYED	LIG_APCC_ABBAyCdc20_2	0.3056
p.H45N	DO51087	PRAD	ICGC	RALLYED	LIG_APCC_ABBAyCdc20_2	0.1389
p.R66H	DO41199	UCEC	ICGC	RALLYED	LIG_APCC_ABBAyCdc20_2	0.1111
p.R66H	SIDM01693	B-Lymphoblastic Leukemia	GDSC	RALLYED	LIG_APCC_ABBAyCdc20_2	0.1111
p.R66H	ACH-000032	Leukemia	CCLE	RALLYED	LIG_APCC_ABBAyCdc20_2	0.1111
p.R66H	ACH-001616	Lymphoma	CCLE	RALLYED	LIG_APCC_ABBAyCdc20_2	0.1111
p.E50K	SIDM01609	Endometrial Carcinoma	GDSC	RALLYED	LIG_APCC_ABBAyCdc20_2	0.2778
p.E50K	ACH-000972	Endometrial/Uterine Cancer	CCLE	RALLYED	LIG_APCC_ABBAyCdc20_2	0.2778
p.L60F	SIDM01612	Endometrial Carcinoma	GDSC	RALLYED	LIG_APCC_ABBAyCdc20_2	0.2778
p.L60F	ACH-000946	Endometrial/Uterine Cancer	CCLE	RALLYED	LIG_APCC_ABBAyCdc20_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q70J99	Protein unc-13 homolog D	LIG_APCC_ABBAyCdc20_2	52:58	RALLYED	APC,CDC20,FZR1	0.7868	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons