DegronMD - Q76LX8(ADAMTS13)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1152T	TCGA-CA-6718	COAD	TCGA	LVPHEE	LIG_APCC_ABBA_1	1138:1143	Mutation rewiring degron network	0.0833
p.A1152T	DO7801	COAD	ICGC	LVPHEE	LIG_APCC_ABBA_1	1138:1143	Mutation rewiring degron network	0.0833
p.R1149W	TCGA-VQ-A8PD	STAD	TCGA	LVPHEE	LIG_APCC_ABBA_1	1138:1143	Mutation rewiring degron network	0.1667
p.R1149W	DO51768	STAD	ICGC	LVPHEE	LIG_APCC_ABBA_1	1138:1143	Mutation rewiring degron network	0.1667
p.R1149W	SIDM00672	Hepatocellular Carcinoma	GDSC	LVPHEE	LIG_APCC_ABBA_1	1138:1143	Mutation rewiring degron network	0.1667
p.R1149W	SIDM00967	Ovarian Carcinoma	GDSC	LVPHEE	LIG_APCC_ABBA_1	1138:1143	Mutation rewiring degron network	0.1667
p.E1144D	DO51863	BLCA	ICGC	LVPHEE	LIG_APCC_ABBA_1	1138:1143	Mutation rewiring degron network	0.3056
p.S1146C	DO44077	BLCA	ICGC	LVPHEE	LIG_APCC_ABBA_1	1138:1143	Mutation rewiring degron network	0.25
p.G1131E	DO228262	BRCA	ICGC	LVPHEE	LIG_APCC_ABBA_1	1138:1143	Mutation rewiring degron network	0.1389
p.A1145T	DO233109	GACA	ICGC	LVPHEE	LIG_APCC_ABBA_1	1138:1143	Mutation rewiring degron network	0.2778
p.P1133S	DO229062	LICA	ICGC	LVPHEE	LIG_APCC_ABBA_1	1138:1143	Mutation rewiring degron network	0.1944
p.G1148R	DO220851	MELA	ICGC	LVPHEE	LIG_APCC_ABBA_1	1138:1143	Mutation rewiring degron network	0.1944
p.V1142I	DO232761	PBCA	ICGC	LVPHEE	LIG_APCC_ABBA_1	1138:1143	Mutation altering degron motif	0.7076
p.R1141C	DO41847	UCEC	ICGC	LVPHEE	LIG_APCC_ABBA_1	1138:1143	Mutation altering degron motif	0.8301
p.E1144Q	TGBC24TKB	biliary tract	COSMIC	LVPHEE	LIG_APCC_ABBA_1	1138:1143	Mutation rewiring degron network	0.3056
p.D1148G	SNU-1040	large intestine	COSMIC	LVPHEE	LIG_APCC_ABBA_1	1138:1143	Mutation rewiring degron network	0.1944
p.G1135A	CAPAN-1	pancreas	COSMIC	LVPHEE	LIG_APCC_ABBA_1	1138:1143	Mutation rewiring degron network	0.25

Kaplan plot for ADAMTS13 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADAMTS13

UniProt ID: Q76LX8

Entrez ID: 11093

Protein name: A disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAM-TS 13) (ADAM-TS13) (ADAMTS-13) (EC 3.4.24.87) (von Willebrand factor-cleaving protease) (vWF-CP) (vWF-cleaving protease)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADAMTS13 in