DegronMD

Uniprot ID: Q76LX8

Source protein: A disintegrin and metalloproteinase with thrombospondin motifs 13

Source gene: ADAMTS13

Class: LIG_APCC_ABBA_1

Location: 1138:1143

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6566

ASA_SCORE: 87.95

COIL: 0.7088

CONS_SCORE: 0.3837

DSS_SCORE: 0.5396

HELIX: 0.146

FCONS_SCORE: 0.9669

RIG_SCORE: 0.7309

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1152T	TCGA-CA-6718	COAD	TCGA	LVPHEE	LIG_APCC_ABBA_1	0.0833
p.A1152T	DO7801	COAD	ICGC	LVPHEE	LIG_APCC_ABBA_1	0.0833
p.R1149W	TCGA-VQ-A8PD	STAD	TCGA	LVPHEE	LIG_APCC_ABBA_1	0.1667
p.R1149W	DO51768	STAD	ICGC	LVPHEE	LIG_APCC_ABBA_1	0.1667
p.R1149W	SIDM00672	Hepatocellular Carcinoma	GDSC	LVPHEE	LIG_APCC_ABBA_1	0.1667
p.R1149W	SIDM00967	Ovarian Carcinoma	GDSC	LVPHEE	LIG_APCC_ABBA_1	0.1667
p.E1144D	DO51863	BLCA	ICGC	LVPHEE	LIG_APCC_ABBA_1	0.3056
p.S1146C	DO44077	BLCA	ICGC	LVPHEE	LIG_APCC_ABBA_1	0.25
p.G1131E	DO228262	BRCA	ICGC	LVPHEE	LIG_APCC_ABBA_1	0.1389
p.A1145T	DO233109	GACA	ICGC	LVPHEE	LIG_APCC_ABBA_1	0.2778
p.P1133S	DO229062	LICA	ICGC	LVPHEE	LIG_APCC_ABBA_1	0.1944
p.G1148R	DO220851	MELA	ICGC	LVPHEE	LIG_APCC_ABBA_1	0.1944
p.V1142I	DO232761	PBCA	ICGC	LVPHEE	LIG_APCC_ABBA_1	0.7076
p.R1141C	DO41847	UCEC	ICGC	LVPHEE	LIG_APCC_ABBA_1	0.8301
p.E1144Q	TGBC24TKB	biliary_tract	COSMIC	LVPHEE	LIG_APCC_ABBA_1	0.3056
p.D1148G	SNU-1040	large_intestine	COSMIC	LVPHEE	LIG_APCC_ABBA_1	0.1944
p.G1135A	CAPAN-1	pancreas	COSMIC	LVPHEE	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q76LX8	A disintegrin and metalloproteinase with thrombospondin motifs 13	LIG_APCC_ABBA_1	1138:1143	LVPHEE	APC,CDC20,FZR1	0.6566	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons