DegronMD - Q7L099(RUFY3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R43Q	TCGA-AJ-A5DW	UCEC	TCGA	ISLTPDPE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.1944
p.R43Q	DO50075	UCEC	ICGC	ISLTPDPE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.1944
p.E44K	TCGA-B5-A1MX	UCEC	TCGA	ISLTPDPE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.2222
p.E44K	DO41999	UCEC	ICGC	ISLTPDPE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.2222
p.P52S	TCGA-BR-7707	STAD	TCGA	ISLTPDPE	DEG_SCF_FBW7_2	48:55	Mutation altering degron motif	0.6752
p.P52S	DO38487	STAD	ICGC	ISLTPDPE	DEG_SCF_FBW7_2	48:55	Mutation altering degron motif	0.6752
p.I48M	TCGA-BT-A3PH	BLCA	TCGA	ISLTPDPE	DEG_SCF_FBW7_2	48:55	Mutation altering degron motif	0.6507
p.I48M	DO856	BLCA	ICGC	ISLTPDPE	DEG_SCF_FBW7_2	48:55	Mutation altering degron motif	0.6507
p.P61S	TCGA-EB-A5UM	SKCM	TCGA	ISLTPDPE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.1667
p.P54S	TCGA-FD-A43P	BLCA	TCGA	ISLTPDPE	DEG_SCF_FBW7_2	48:55	Mutation altering degron motif	0.5641
p.P54S	DO44049	BLCA	ICGC	ISLTPDPE	DEG_SCF_FBW7_2	48:55	Mutation altering degron motif	0.5641
p.T51K	TCGA-KL-8330	KICH	TCGA	ISLTPDPE	DEG_SCF_FBW7_2	48:55	Mutation altering degron motif	0.7306
p.T51K	DO220338	KICH	ICGC	ISLTPDPE	DEG_SCF_FBW7_2	48:55	Mutation altering degron motif	0.7306
p.W39L	TCGA-MH-A561	KIRP	TCGA	ISLTPDPE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.0833
p.W39L	DO48509	KIRP	ICGC	ISLTPDPE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.0833
p.E59V	DO223009	ESCA	ICGC	ISLTPDPE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.2222
p.D60Y	DO229006	LICA	ICGC	ISLTPDPE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.1944
p.E43Q	ACH-000427	Gastric Cancer	CCLE	ISLTPDPE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.1944

Kaplan plot for RUFY3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RUFY3

UniProt ID: Q7L099

Entrez ID: 22902

Protein name: Protein RUFY3 (RUN and FYVE domain-containing protein 3) (Rap2-interacting protein x) (RIPx) (Single axon-regulated protein) (Singar)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RUFY3 in