DegronMD

Uniprot ID: Q7L099

Source protein: Protein RUFY3

Source gene: RUFY3

Class: DEG_SCF_FBW7_2

Location: 48:55

E3 ligase: FBXW7

DEGRON score: 0.7945

ASA_SCORE: 83.7125

COIL: 0.9386

CONS_SCORE: 0.2494

DSS_SCORE: 0.4503

HELIX: 0.0336

FCONS_SCORE: 0.7219

RIG_SCORE: 0.6777

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R43Q	TCGA-AJ-A5DW	UCEC	TCGA	ISLTPDPE	DEG_SCF_FBW7_2	0.1944
p.R43Q	DO50075	UCEC	ICGC	ISLTPDPE	DEG_SCF_FBW7_2	0.1944
p.E44K	TCGA-B5-A1MX	UCEC	TCGA	ISLTPDPE	DEG_SCF_FBW7_2	0.2222
p.E44K	DO41999	UCEC	ICGC	ISLTPDPE	DEG_SCF_FBW7_2	0.2222
p.P52S	TCGA-BR-7707	STAD	TCGA	ISLTPDPE	DEG_SCF_FBW7_2	0.6752
p.P52S	DO38487	STAD	ICGC	ISLTPDPE	DEG_SCF_FBW7_2	0.6752
p.I48M	TCGA-BT-A3PH	BLCA	TCGA	ISLTPDPE	DEG_SCF_FBW7_2	0.6507
p.I48M	DO856	BLCA	ICGC	ISLTPDPE	DEG_SCF_FBW7_2	0.6507
p.P61S	TCGA-EB-A5UM	SKCM	TCGA	ISLTPDPE	DEG_SCF_FBW7_2	0.1667
p.P54S	TCGA-FD-A43P	BLCA	TCGA	ISLTPDPE	DEG_SCF_FBW7_2	0.5641
p.P54S	DO44049	BLCA	ICGC	ISLTPDPE	DEG_SCF_FBW7_2	0.5641
p.T51K	TCGA-KL-8330	KICH	TCGA	ISLTPDPE	DEG_SCF_FBW7_2	0.7306
p.T51K	DO220338	KICH	ICGC	ISLTPDPE	DEG_SCF_FBW7_2	0.7306
p.W39L	TCGA-MH-A561	KIRP	TCGA	ISLTPDPE	DEG_SCF_FBW7_2	0.0833
p.W39L	DO48509	KIRP	ICGC	ISLTPDPE	DEG_SCF_FBW7_2	0.0833
p.E59V	DO223009	ESCA	ICGC	ISLTPDPE	DEG_SCF_FBW7_2	0.2222
p.D60Y	DO229006	LICA	ICGC	ISLTPDPE	DEG_SCF_FBW7_2	0.1944
p.E43Q	ACH-000427	Gastric Cancer	CCLE	ISLTPDPE	DEG_SCF_FBW7_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7L099	Protein RUFY3	DEG_SCF_FBW7_2	48:55	ISLTPDPE	FBXW7	0.7945	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons