DegronMD - Q7L513(FCRLA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P297L	TCGA-06-0132	GBM	TCGA	PPPTPSSE	DEG_SCF_FBW7_2	295:302	Mutation altering degron motif	0.6471
p.G285C	TCGA-91-A4BC	LUAD	TCGA	PPPTPSSE	DEG_SCF_FBW7_2	295:302	Mutation rewiring degron network	0.0556
p.P309H	TCGA-AX-A2HA	UCEC	TCGA	PPPTPSSE	DEG_SCF_FBW7_2	295:302	Mutation rewiring degron network	0.1389
p.P305L	TCGA-EB-A85J	SKCM	TCGA	PPPTPSSE	DEG_SCF_FBW7_2	295:302	Mutation rewiring degron network	0.25
p.S302L	TCGA-FW-A3TV	SKCM	TCGA	PPPTPSSE	DEG_SCF_FBW7_2	295:302	Mutation altering degron motif	0.7667
p.A286V	DO25416	LUAD	ICGC	PPPTPSSE	DEG_SCF_FBW7_2	295:302	Mutation rewiring degron network	0.0833
p.E311K	SIDM00007	Other Solid Cancers	GDSC	PPPTPSSE	DEG_SCF_FBW7_2	295:302	Mutation rewiring degron network	0.0833
p.E311K	MCC13	skin	COSMIC	PPPTPSSE	DEG_SCF_FBW7_2	295:302	Mutation rewiring degron network	0.0833
p.P292L	SIDM00293	Small Cell Lung Carcinoma	GDSC	PPPTPSSE	DEG_SCF_FBW7_2	295:302	Mutation rewiring degron network	0.25
p.P292L	LU-139	lung	COSMIC	PPPTPSSE	DEG_SCF_FBW7_2	295:302	Mutation rewiring degron network	0.25
p.E305K	ACH-001550	Skin Cancer	CCLE	PPPTPSSE	DEG_SCF_FBW7_2	295:302	Mutation rewiring degron network	0.25
p.E305K	MCC13	skin	COSMIC	PPPTPSSE	DEG_SCF_FBW7_2	295:302	Mutation rewiring degron network	0.25
p.T288A	ACH-001991	Primary	CCLE	PPPTPSSE	DEG_SCF_FBW7_2	295:302	Mutation rewiring degron network	0.1389
p.P286L	ACH-002052	Lung Cancer	CCLE	PPPTPSSE	DEG_SCF_FBW7_2	295:302	Mutation rewiring degron network	0.0833
p.P286L	LU-139	lung	COSMIC	PPPTPSSE	DEG_SCF_FBW7_2	295:302	Mutation rewiring degron network	0.0833
p.E294K	MCC13	skin	COSMIC	PPPTPSSE	DEG_SCF_FBW7_2	295:302	Mutation rewiring degron network	0.3056
p.S307A	Daoy	central nervous system	COSMIC	PPPTPSSE	DEG_SCF_FBW7_2	295:302	Mutation rewiring degron network	0.1944
p.P303S	SNU-1040	large intestine	COSMIC	PPPTPSSE	DEG_SCF_FBW7_2	295:302	Mutation rewiring degron network	0.3056

Kaplan plot for FCRLA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FCRLA

UniProt ID: Q7L513

Entrez ID: 84824

Protein name: Fc receptor-like A (Fc receptor homolog expressed in B-cells) (Fc receptor-like and mucin-like protein 1) (Fc receptor-like protein) (Fc receptor-related protein X) (FcRX)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FCRLA in