DegronMD

Uniprot ID: Q7L513

Source protein: Fc receptor-like A

Source gene: FCRLA

Class: DEG_SCF_FBW7_2

Location: 295:302

E3 ligase: FBXW7

DEGRON score: 0.9703

ASA_SCORE: 85.6875

COIL: 0.9429

CONS_SCORE: 0.5803

DSS_SCORE: 0.8352

HELIX: 0.0333

FCONS_SCORE: 1.0535

RIG_SCORE: 0.4654

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P297L	TCGA-06-0132	GBM	TCGA	PPPTPSSE	DEG_SCF_FBW7_2	0.6471
p.G285C	TCGA-91-A4BC	LUAD	TCGA	PPPTPSSE	DEG_SCF_FBW7_2	0.0556
p.P309H	TCGA-AX-A2HA	UCEC	TCGA	PPPTPSSE	DEG_SCF_FBW7_2	0.1389
p.P305L	TCGA-EB-A85J	SKCM	TCGA	PPPTPSSE	DEG_SCF_FBW7_2	0.25
p.S302L	TCGA-FW-A3TV	SKCM	TCGA	PPPTPSSE	DEG_SCF_FBW7_2	0.7667
p.A286V	DO25416	LUAD	ICGC	PPPTPSSE	DEG_SCF_FBW7_2	0.0833
p.E311K	SIDM00007	Other Solid Cancers	GDSC	PPPTPSSE	DEG_SCF_FBW7_2	0.0833
p.E311K	MCC13	skin	COSMIC	PPPTPSSE	DEG_SCF_FBW7_2	0.0833
p.P292L	SIDM00293	Small Cell Lung Carcinoma	GDSC	PPPTPSSE	DEG_SCF_FBW7_2	0.25
p.P292L	LU-139	lung	COSMIC	PPPTPSSE	DEG_SCF_FBW7_2	0.25
p.E305K	ACH-001550	Skin Cancer	CCLE	PPPTPSSE	DEG_SCF_FBW7_2	0.25
p.E305K	MCC13	skin	COSMIC	PPPTPSSE	DEG_SCF_FBW7_2	0.25
p.T288A	ACH-001991	Primary	CCLE	PPPTPSSE	DEG_SCF_FBW7_2	0.1389
p.P286L	ACH-002052	Lung Cancer	CCLE	PPPTPSSE	DEG_SCF_FBW7_2	0.0833
p.P286L	LU-139	lung	COSMIC	PPPTPSSE	DEG_SCF_FBW7_2	0.0833
p.E294K	MCC13	skin	COSMIC	PPPTPSSE	DEG_SCF_FBW7_2	0.3056
p.S307A	Daoy	central_nervous_system	COSMIC	PPPTPSSE	DEG_SCF_FBW7_2	0.1944
p.P303S	SNU-1040	large_intestine	COSMIC	PPPTPSSE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7L513	Fc receptor-like A	DEG_SCF_FBW7_2	295:302	PPPTPSSE	FBXW7	0.9703	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons