DegronMD - Q7L8S5(OTUD6A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G217E	TCGA-49-AAQV	LUAD	TCGA	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.0833
p.G217E	DO218916	LUAD	ICGC	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.0833
p.R212L	TCGA-50-5930	LUAD	TCGA	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.2222
p.R212L	DO25189	LUAD	ICGC	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.2222
p.T214M	TCGA-A2-A0SY	BRCA	TCGA	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation blocking phosphorylation signal	0.6111
p.T214M	TCGA-AA-3947	COAD	TCGA	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation blocking phosphorylation signal	0.6111
p.T214M	TCGA-MX-A5UJ	STAD	TCGA	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation blocking phosphorylation signal	0.6111
p.T214M	DO2961	BRCA	ICGC	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation blocking phosphorylation signal	0.6111
p.T214M	DO8192	COAD	ICGC	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation blocking phosphorylation signal	0.6111
p.T214M	DO45299	LIRI	ICGC	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation blocking phosphorylation signal	0.6111
p.T214M	DO48547	STAD	ICGC	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation blocking phosphorylation signal	0.6111
p.C207Y	TCGA-A5-A0VQ	UCEC	TCGA	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.5976
p.C207Y	DO42113	UCEC	ICGC	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.5976
p.R212C	TCGA-AJ-A3OL	UCEC	TCGA	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.2222
p.R212C	DO228869	MALY	ICGC	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.2222
p.R212C	DO43001	UCEC	ICGC	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.2222
p.D201E	TCGA-B5-A1MV	UCEC	TCGA	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.2778
p.D201E	DO43354	UCEC	ICGC	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.2778
p.V211M	TCGA-BG-A0YV	UCEC	TCGA	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.25
p.V211M	DO228247	BRCA	ICGC	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.25
p.V211M	DO41428	UCEC	ICGC	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.25
p.M204I	TCGA-CV-7568	HNSC	TCGA	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.6507
p.M204I	TCGA-DA-A95W	SKCM	TCGA	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.6507
p.M204I	TCGA-FR-A726	SKCM	TCGA	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.6507
p.M204I	DO14160	HNSC	ICGC	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.6507
p.M204I	DO222875	MELA	ICGC	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.6507
p.M204I	DO48665	SKCM	ICGC	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.6507
p.M204I	DO219479	SKCM	ICGC	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.6507
p.V211L	TCGA-E3-A3DZ	THCA	TCGA	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.25
p.V211L	DO40215	THCA	ICGC	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.25
p.E193K	TCGA-EE-A20F	SKCM	TCGA	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.0556
p.E193K	TCGA-LH-A9QB	SKCM	TCGA	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.0556
p.E193K	DO37961	SKCM	ICGC	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.0556
p.E193K	DO51266	SKCM	ICGC	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.0556
p.F203V	DO50398	ESAD	ICGC	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.5957
p.S195N	SIDM01156	Small Cell Lung Carcinoma	GDSC	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1111
p.S195N	ACH-000890	Lung Cancer	CCLE	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1111
p.S195N	SW1271	lung	COSMIC	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1111
p.D202N	SIDM00541	Colorectal Carcinoma	GDSC	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.3056
p.D202N	ACH-000926	Colon/Colorectal Cancer	CCLE	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.3056
p.D202N	HT55	large intestine	COSMIC	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.3056
p.D196N	SIDM00282	Colorectal Carcinoma	GDSC	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1389
p.D196N	ACH-000998	Colon/Colorectal Cancer	CCLE	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1389
p.D196N	CW-2	large intestine	COSMIC	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1389
p.R212H	SIDM00878	Breast Carcinoma	GDSC	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.2222
p.R212H	ACH-000930	Breast Cancer	CCLE	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.2222
p.R212H	HCC1569	breast	COSMIC	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.2222
p.S195G	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1111
p.S195G	ACH-000875	Lung Cancer	CCLE	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1111
p.S195G	NCI-H2347	lung	COSMIC	FMIYCD	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OTUD6A

UniProt ID: Q7L8S5

Entrez ID: 139562

Protein name: OTU domain-containing protein 6A (EC 3.4.19.12) (DUBA-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OTUD6A in