DegronMD

Uniprot ID: Q7L8S5

Source protein: OTU domain-containing protein 6A

Source gene: OTUD6A

Class: LIG_APCC_ABBA_1

Location: 203:208

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6692

ASA_SCORE: 39.9

COIL: 0.0062

CONS_SCORE: 0.5415

DSS_SCORE: 0.0509

HELIX: 0.9922

FCONS_SCORE: 1.267

RIG_SCORE: 0.9705

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M204I	TCGA-CV-7568	HNSC	TCGA	FMIYCD	LIG_APCC_ABBA_1	0.6507
p.M204I	TCGA-DA-A95W	SKCM	TCGA	FMIYCD	LIG_APCC_ABBA_1	0.6507
p.M204I	TCGA-FR-A726	SKCM	TCGA	FMIYCD	LIG_APCC_ABBA_1	0.6507
p.M204I	DO14160	HNSC	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.6507
p.M204I	DO222875	MELA	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.6507
p.M204I	DO48665	SKCM	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.6507
p.M204I	DO219479	SKCM	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.6507
p.T214M	TCGA-A2-A0SY	BRCA	TCGA	FMIYCD	LIG_APCC_ABBA_1	0.6111
p.T214M	TCGA-AA-3947	COAD	TCGA	FMIYCD	LIG_APCC_ABBA_1	0.6111
p.T214M	TCGA-MX-A5UJ	STAD	TCGA	FMIYCD	LIG_APCC_ABBA_1	0.6111
p.T214M	DO2961	BRCA	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.6111
p.T214M	DO8192	COAD	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.6111
p.T214M	DO45299	LIRI	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.6111
p.T214M	DO48547	STAD	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.6111
p.C207Y	TCGA-A5-A0VQ	UCEC	TCGA	FMIYCD	LIG_APCC_ABBA_1	0.5976
p.C207Y	DO42113	UCEC	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.5976
p.F203V	DO50398	ESAD	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.5957
p.D202N	SIDM00541	Colorectal Carcinoma	GDSC	FMIYCD	LIG_APCC_ABBA_1	0.3056
p.D202N	ACH-000926	Colon/Colorectal Cancer	CCLE	FMIYCD	LIG_APCC_ABBA_1	0.3056
p.D202N	HT55	large_intestine	COSMIC	FMIYCD	LIG_APCC_ABBA_1	0.3056
p.D201E	TCGA-B5-A1MV	UCEC	TCGA	FMIYCD	LIG_APCC_ABBA_1	0.2778
p.D201E	DO43354	UCEC	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.2778
p.V211M	TCGA-BG-A0YV	UCEC	TCGA	FMIYCD	LIG_APCC_ABBA_1	0.25
p.V211M	DO228247	BRCA	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.25
p.V211M	DO41428	UCEC	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.25

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7L8S5	OTU domain-containing protein 6A	LIG_APCC_ABBA_1	203:208	FMIYCD	APC,CDC20,FZR1	0.6692	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons