DegronMD

Uniprot ID: Q7L8S5

Source protein: OTU domain-containing protein 6A

Source gene: OTUD6A

Class: LIG_APCC_ABBA_1

Location: 203:208

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6692

ASA_SCORE: 39.9

COIL: 0.0062

CONS_SCORE: 0.5415

DSS_SCORE: 0.0509

HELIX: 0.9922

FCONS_SCORE: 1.267

RIG_SCORE: 0.9705

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G217E	TCGA-49-AAQV	LUAD	TCGA	FMIYCD	LIG_APCC_ABBA_1	0.0833
p.G217E	DO218916	LUAD	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.0833
p.R212L	TCGA-50-5930	LUAD	TCGA	FMIYCD	LIG_APCC_ABBA_1	0.2222
p.R212L	DO25189	LUAD	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.2222
p.T214M	TCGA-A2-A0SY	BRCA	TCGA	FMIYCD	LIG_APCC_ABBA_1	0.6111
p.T214M	TCGA-AA-3947	COAD	TCGA	FMIYCD	LIG_APCC_ABBA_1	0.6111
p.T214M	TCGA-MX-A5UJ	STAD	TCGA	FMIYCD	LIG_APCC_ABBA_1	0.6111
p.T214M	DO2961	BRCA	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.6111
p.T214M	DO8192	COAD	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.6111
p.T214M	DO45299	LIRI	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.6111
p.T214M	DO48547	STAD	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.6111
p.C207Y	TCGA-A5-A0VQ	UCEC	TCGA	FMIYCD	LIG_APCC_ABBA_1	0.5976
p.C207Y	DO42113	UCEC	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.5976
p.R212C	TCGA-AJ-A3OL	UCEC	TCGA	FMIYCD	LIG_APCC_ABBA_1	0.2222
p.R212C	DO228869	MALY	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.2222
p.R212C	DO43001	UCEC	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.2222
p.D201E	TCGA-B5-A1MV	UCEC	TCGA	FMIYCD	LIG_APCC_ABBA_1	0.2778
p.D201E	DO43354	UCEC	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.2778
p.V211M	TCGA-BG-A0YV	UCEC	TCGA	FMIYCD	LIG_APCC_ABBA_1	0.25
p.V211M	DO228247	BRCA	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.25
p.V211M	DO41428	UCEC	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.25
p.M204I	TCGA-CV-7568	HNSC	TCGA	FMIYCD	LIG_APCC_ABBA_1	0.6507
p.M204I	TCGA-DA-A95W	SKCM	TCGA	FMIYCD	LIG_APCC_ABBA_1	0.6507
p.M204I	TCGA-FR-A726	SKCM	TCGA	FMIYCD	LIG_APCC_ABBA_1	0.6507
p.M204I	DO14160	HNSC	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.6507
p.M204I	DO222875	MELA	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.6507
p.M204I	DO48665	SKCM	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.6507
p.M204I	DO219479	SKCM	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.6507
p.V211L	TCGA-E3-A3DZ	THCA	TCGA	FMIYCD	LIG_APCC_ABBA_1	0.25
p.V211L	DO40215	THCA	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.25
p.E193K	TCGA-EE-A20F	SKCM	TCGA	FMIYCD	LIG_APCC_ABBA_1	0.0556
p.E193K	TCGA-LH-A9QB	SKCM	TCGA	FMIYCD	LIG_APCC_ABBA_1	0.0556
p.E193K	DO37961	SKCM	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.0556
p.E193K	DO51266	SKCM	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.0556
p.F203V	DO50398	ESAD	ICGC	FMIYCD	LIG_APCC_ABBA_1	0.5957
p.S195N	SIDM01156	Small Cell Lung Carcinoma	GDSC	FMIYCD	LIG_APCC_ABBA_1	0.1111
p.S195N	ACH-000890	Lung Cancer	CCLE	FMIYCD	LIG_APCC_ABBA_1	0.1111
p.S195N	SW1271	lung	COSMIC	FMIYCD	LIG_APCC_ABBA_1	0.1111
p.D202N	SIDM00541	Colorectal Carcinoma	GDSC	FMIYCD	LIG_APCC_ABBA_1	0.3056
p.D202N	ACH-000926	Colon/Colorectal Cancer	CCLE	FMIYCD	LIG_APCC_ABBA_1	0.3056
p.D202N	HT55	large_intestine	COSMIC	FMIYCD	LIG_APCC_ABBA_1	0.3056
p.D196N	SIDM00282	Colorectal Carcinoma	GDSC	FMIYCD	LIG_APCC_ABBA_1	0.1389
p.D196N	ACH-000998	Colon/Colorectal Cancer	CCLE	FMIYCD	LIG_APCC_ABBA_1	0.1389
p.D196N	CW-2	large_intestine	COSMIC	FMIYCD	LIG_APCC_ABBA_1	0.1389
p.R212H	SIDM00878	Breast Carcinoma	GDSC	FMIYCD	LIG_APCC_ABBA_1	0.2222
p.R212H	ACH-000930	Breast Cancer	CCLE	FMIYCD	LIG_APCC_ABBA_1	0.2222
p.R212H	HCC1569	breast	COSMIC	FMIYCD	LIG_APCC_ABBA_1	0.2222
p.S195G	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	FMIYCD	LIG_APCC_ABBA_1	0.1111
p.S195G	ACH-000875	Lung Cancer	CCLE	FMIYCD	LIG_APCC_ABBA_1	0.1111
p.S195G	NCI-H2347	lung	COSMIC	FMIYCD	LIG_APCC_ABBA_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FMIYCD

Degron related mutations and impact score

Drug responses associated with OTUD6A mutations

All proteins holding degron of FMIYCD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7L8S5	OTU domain-containing protein 6A	LIG_APCC_ABBA_1	203:208	FMIYCD	APC,CDC20,FZR1	0.6692	More...