DegronMD - Q7L9B9(EEPD1)

GO - Biological processes (BP): DNA repair [GO:0006281]; positive regulation of cholesterol efflux [GO:0010875]

GO - Molecular function (MF): DNA binding [GO:0003677]

GO - Cellular component (CC): anchored component of plasma membrane [GO:0046658]; plasma membrane [GO:0005886]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V195A	SIDM00878	Breast Carcinoma	GDSC	RHQVFAE	LIG_APCC_ABBAyCdc20_2	192:198	Mutation altering degron motif	0.6936
p.V195A	ACH-000930	Breast Cancer	CCLE	RHQVFAE	LIG_APCC_ABBAyCdc20_2	192:198	Mutation altering degron motif	0.6936
p.V195A	HCC1569	breast	COSMIC	RHQVFAE	LIG_APCC_ABBAyCdc20_2	192:198	Mutation altering degron motif	0.6936
p.Q194H	TCGA-2W-A8YY	CESC	TCGA	RHQVFAE	LIG_APCC_ABBAyCdc20_2	192:198	Mutation altering degron motif	0.647
p.Q194H	DO223732	CESC	ICGC	RHQVFAE	LIG_APCC_ABBAyCdc20_2	192:198	Mutation altering degron motif	0.647
p.R201S	SIDM01611	Endometrial Carcinoma	GDSC	RHQVFAE	LIG_APCC_ABBAyCdc20_2	192:198	Mutation rewiring degron network	0.25
p.R201S	ACH-000996	Endometrial/Uterine Cancer	CCLE	RHQVFAE	LIG_APCC_ABBAyCdc20_2	192:198	Mutation rewiring degron network	0.25
p.P202S	TCGA-D3-A3MU	SKCM	TCGA	RHQVFAE	LIG_APCC_ABBAyCdc20_2	192:198	Mutation rewiring degron network	0.2222
p.P202S	DO47337	SKCM	ICGC	RHQVFAE	LIG_APCC_ABBAyCdc20_2	192:198	Mutation rewiring degron network	0.2222
p.A186T	TCGA-B5-A3FC	UCEC	TCGA	RHQVFAE	LIG_APCC_ABBAyCdc20_2	192:198	Mutation rewiring degron network	0.1667
p.A186T	DO41871	UCEC	ICGC	RHQVFAE	LIG_APCC_ABBAyCdc20_2	192:198	Mutation rewiring degron network	0.1667
p.A185V	TCGA-DU-6407	LGG	TCGA	RHQVFAE	LIG_APCC_ABBAyCdc20_2	192:198	Mutation rewiring degron network	0.1389
p.A185V	DO22295	LGG	ICGC	RHQVFAE	LIG_APCC_ABBAyCdc20_2	192:198	Mutation rewiring degron network	0.1389
p.N184S	SIDM01057	Acute Myeloid Leukemia	GDSC	RHQVFAE	LIG_APCC_ABBAyCdc20_2	192:198	Mutation rewiring degron network	0.1111
p.N184S	SIDM00311	Mesothelioma	GDSC	RHQVFAE	LIG_APCC_ABBAyCdc20_2	192:198	Mutation rewiring degron network	0.1111
p.N184S	SIDM01120	Other Solid Cancers	GDSC	RHQVFAE	LIG_APCC_ABBAyCdc20_2	192:198	Mutation rewiring degron network	0.1111
p.N184S	SIDM01397	Melanoma	GDSC	RHQVFAE	LIG_APCC_ABBAyCdc20_2	192:198	Mutation rewiring degron network	0.1111
p.G182D	SIDM01182	Bladder Carcinoma	GDSC	RHQVFAE	LIG_APCC_ABBAyCdc20_2	192:198	Mutation rewiring degron network	0.0556
p.G182D	ACH-000522	Bladder Cancer	CCLE	RHQVFAE	LIG_APCC_ABBAyCdc20_2	192:198	Mutation rewiring degron network	0.0556
p.G182D	UM-UC-3	urinary tract	COSMIC	RHQVFAE	LIG_APCC_ABBAyCdc20_2	192:198	Mutation rewiring degron network	0.0556

Showing 1 to 20 of 20 entries

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No resistance data available for this Degron.

Kaplan plot for EEPD1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EEPD1

UniProt ID: Q7L9B9

Entrez ID: 80820

Protein name: Endonuclease/exonuclease/phosphatase family domain-containing protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for EEPD1 in