DegronMD

Uniprot ID: Q7L9B9

Source protein: Endonuclease/exonuclease/phosphatase family domain-containing protein 1

Source gene: EEPD1

Class: LIG_APCC_ABBAyCdc20_2

Location: 192:198

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8827

ASA_SCORE: 57.1857

COIL: 0.3534

CONS_SCORE: 0.4224

DSS_SCORE: 0.45

HELIX: 0.1389

FCONS_SCORE: 0.9947

RIG_SCORE: 0.7943

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q194H	TCGA-2W-A8YY	CESC	TCGA	RHQVFAE	LIG_APCC_ABBAyCdc20_2	0.647
p.Q194H	DO223732	CESC	ICGC	RHQVFAE	LIG_APCC_ABBAyCdc20_2	0.647
p.A186T	TCGA-B5-A3FC	UCEC	TCGA	RHQVFAE	LIG_APCC_ABBAyCdc20_2	0.1667
p.A186T	DO41871	UCEC	ICGC	RHQVFAE	LIG_APCC_ABBAyCdc20_2	0.1667
p.P202S	TCGA-D3-A3MU	SKCM	TCGA	RHQVFAE	LIG_APCC_ABBAyCdc20_2	0.2222
p.P202S	DO47337	SKCM	ICGC	RHQVFAE	LIG_APCC_ABBAyCdc20_2	0.2222
p.A185V	TCGA-DU-6407	LGG	TCGA	RHQVFAE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A185V	DO22295	LGG	ICGC	RHQVFAE	LIG_APCC_ABBAyCdc20_2	0.1389
p.N184S	SIDM01057	Acute Myeloid Leukemia	GDSC	RHQVFAE	LIG_APCC_ABBAyCdc20_2	0.1111
p.N184S	SIDM00311	Mesothelioma	GDSC	RHQVFAE	LIG_APCC_ABBAyCdc20_2	0.1111
p.N184S	SIDM01120	Other Solid Cancers	GDSC	RHQVFAE	LIG_APCC_ABBAyCdc20_2	0.1111
p.N184S	SIDM01397	Melanoma	GDSC	RHQVFAE	LIG_APCC_ABBAyCdc20_2	0.1111
p.V195A	SIDM00878	Breast Carcinoma	GDSC	RHQVFAE	LIG_APCC_ABBAyCdc20_2	0.6936
p.V195A	ACH-000930	Breast Cancer	CCLE	RHQVFAE	LIG_APCC_ABBAyCdc20_2	0.6936
p.V195A	HCC1569	breast	COSMIC	RHQVFAE	LIG_APCC_ABBAyCdc20_2	0.6936
p.G182D	SIDM01182	Bladder Carcinoma	GDSC	RHQVFAE	LIG_APCC_ABBAyCdc20_2	0.0556
p.G182D	ACH-000522	Bladder Cancer	CCLE	RHQVFAE	LIG_APCC_ABBAyCdc20_2	0.0556
p.G182D	UM-UC-3	urinary_tract	COSMIC	RHQVFAE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R201S	SIDM01611	Endometrial Carcinoma	GDSC	RHQVFAE	LIG_APCC_ABBAyCdc20_2	0.25
p.R201S	ACH-000996	Endometrial/Uterine Cancer	CCLE	RHQVFAE	LIG_APCC_ABBAyCdc20_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7L9B9	Endonuclease/exonuclease/phosphatase family domain-containing protein 1	LIG_APCC_ABBAyCdc20_2	192:198	RHQVFAE	APC,CDC20,FZR1	0.8827	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons