DegronMD - Q7LDG7(RASGRP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V124I	TCGA-AA-3864	COAD	TCGA	SSLIDIDSVPTY	DEG_COP1_1	116:127	Mutation altering degron motif	0.7076
p.V124I	DO8490	COAD	ICGC	SSLIDIDSVPTY	DEG_COP1_1	116:127	Mutation altering degron motif	0.7076
p.S117N	TCGA-AA-3984	COAD	TCGA	SSLIDIDSVPTY	DEG_COP1_1	116:127	Mutation altering degron motif	0.818
p.S117N	DO9002	COAD	ICGC	SSLIDIDSVPTY	DEG_COP1_1	116:127	Mutation altering degron motif	0.818
p.R131L	TCGA-D3-A3CE	SKCM	TCGA	SSLIDIDSVPTY	DEG_COP1_1	116:127	Mutation rewiring degron network	0.2222
p.R131L	DO37405	SKCM	ICGC	SSLIDIDSVPTY	DEG_COP1_1	116:127	Mutation rewiring degron network	0.2222
p.R113Q	TCGA-DK-A2I4	BLCA	TCGA	SSLIDIDSVPTY	DEG_COP1_1	116:127	Mutation rewiring degron network	0.25
p.R113Q	DO465	BLCA	ICGC	SSLIDIDSVPTY	DEG_COP1_1	116:127	Mutation rewiring degron network	0.25
p.R113Q	DO8730	COAD	ICGC	SSLIDIDSVPTY	DEG_COP1_1	116:127	Mutation rewiring degron network	0.25
p.R113Q	SIDM00217	Colorectal Carcinoma	GDSC	SSLIDIDSVPTY	DEG_COP1_1	116:127	Mutation rewiring degron network	0.25
p.R113Q	ACH-000999	Colon/Colorectal Cancer	CCLE	SSLIDIDSVPTY	DEG_COP1_1	116:127	Mutation rewiring degron network	0.25
p.R113Q	SNU-1040	large intestine	COSMIC	SSLIDIDSVPTY	DEG_COP1_1	116:127	Mutation rewiring degron network	0.25
p.R114Q	TCGA-GM-A3XL	BRCA	TCGA	SSLIDIDSVPTY	DEG_COP1_1	116:127	Mutation rewiring degron network	0.2778
p.R114Q	DO44111	BRCA	ICGC	SSLIDIDSVPTY	DEG_COP1_1	116:127	Mutation rewiring degron network	0.2778
p.K128N	DO224892	BRCA	ICGC	SSLIDIDSVPTY	DEG_COP1_1	116:127	Mutation blocking ubiquitination signal	0.75
p.K128N	DO52553	BRCA	ICGC	SSLIDIDSVPTY	DEG_COP1_1	116:127	Mutation blocking ubiquitination signal	0.75
p.K130N	SIDM01004	Chronic Myelogenous Leukemia	GDSC	SSLIDIDSVPTY	DEG_COP1_1	116:127	Mutation substituting flanking lysine	0.3611
p.K130N	ACH-000983	Leukemia	CCLE	SSLIDIDSVPTY	DEG_COP1_1	116:127	Mutation substituting flanking lysine	0.3611
p.K130N	KCL-22	haematopoietic and lymphoid tissue	COSMIC	SSLIDIDSVPTY	DEG_COP1_1	116:127	Mutation substituting flanking lysine	0.3611
p.L118V	SIDM00865	Small Cell Lung Carcinoma	GDSC	SSLIDIDSVPTY	DEG_COP1_1	116:127	Mutation altering degron motif	0.5654
p.L118V	ACH-000530	Lung Cancer	CCLE	SSLIDIDSVPTY	DEG_COP1_1	116:127	Mutation altering degron motif	0.5654
p.L118V	DMS-114	lung	COSMIC	SSLIDIDSVPTY	DEG_COP1_1	116:127	Mutation altering degron motif	0.5654
p.D120N	SIDM00153	T-Lymphoblastic Leukemia	GDSC	SSLIDIDSVPTY	DEG_COP1_1	116:127	Mutation altering degron motif	0.6932
p.D120N	ACH-000964	Leukemia	CCLE	SSLIDIDSVPTY	DEG_COP1_1	116:127	Mutation altering degron motif	0.6932
p.L107I	ACH-000681	Lung Cancer	CCLE	SSLIDIDSVPTY	DEG_COP1_1	116:127	Mutation rewiring degron network	0.0833

Kaplan plot for RASGRP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RASGRP2

UniProt ID: Q7LDG7

Entrez ID: 10235

Protein name: RAS guanyl-releasing protein 2 (Calcium and DAG-regulated guanine nucleotide exchange factor I) (CalDAG-GEFI) (Cdc25-like protein) (hCDC25L) (F25B3.3 kinase-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RASGRP2 in