DegronMD

Uniprot ID: Q7LDG7

Source protein: RAS guanyl-releasing protein 2

Source gene: RASGRP2

Class: DEG_COP1_1

Location: 116:127

E3 ligase: COP1

DEGRON score: 0.5824

ASA_SCORE: 70.4167

COIL: 0.6133

CONS_SCORE: 0.5821

DSS_SCORE: 0.366

HELIX: 0.321

FCONS_SCORE: 1.0875

RIG_SCORE: 0.7563

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V124I	TCGA-AA-3864	COAD	TCGA	SSLIDIDSVPTY	DEG_COP1_1	0.7076
p.V124I	DO8490	COAD	ICGC	SSLIDIDSVPTY	DEG_COP1_1	0.7076
p.S117N	TCGA-AA-3984	COAD	TCGA	SSLIDIDSVPTY	DEG_COP1_1	0.818
p.S117N	DO9002	COAD	ICGC	SSLIDIDSVPTY	DEG_COP1_1	0.818
p.R131L	TCGA-D3-A3CE	SKCM	TCGA	SSLIDIDSVPTY	DEG_COP1_1	0.2222
p.R131L	DO37405	SKCM	ICGC	SSLIDIDSVPTY	DEG_COP1_1	0.2222
p.R113Q	TCGA-DK-A2I4	BLCA	TCGA	SSLIDIDSVPTY	DEG_COP1_1	0.25
p.R113Q	DO465	BLCA	ICGC	SSLIDIDSVPTY	DEG_COP1_1	0.25
p.R113Q	DO8730	COAD	ICGC	SSLIDIDSVPTY	DEG_COP1_1	0.25
p.R113Q	SIDM00217	Colorectal Carcinoma	GDSC	SSLIDIDSVPTY	DEG_COP1_1	0.25
p.R113Q	ACH-000999	Colon/Colorectal Cancer	CCLE	SSLIDIDSVPTY	DEG_COP1_1	0.25
p.R113Q	SNU-1040	large_intestine	COSMIC	SSLIDIDSVPTY	DEG_COP1_1	0.25
p.R114Q	TCGA-GM-A3XL	BRCA	TCGA	SSLIDIDSVPTY	DEG_COP1_1	0.2778
p.R114Q	DO44111	BRCA	ICGC	SSLIDIDSVPTY	DEG_COP1_1	0.2778
p.K128N	DO224892	BRCA	ICGC	SSLIDIDSVPTY	DEG_COP1_1	0.75
p.K128N	DO52553	BRCA	ICGC	SSLIDIDSVPTY	DEG_COP1_1	0.75
p.K130N	SIDM01004	Chronic Myelogenous Leukemia	GDSC	SSLIDIDSVPTY	DEG_COP1_1	0.3611
p.K130N	ACH-000983	Leukemia	CCLE	SSLIDIDSVPTY	DEG_COP1_1	0.3611
p.K130N	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	SSLIDIDSVPTY	DEG_COP1_1	0.3611
p.L118V	SIDM00865	Small Cell Lung Carcinoma	GDSC	SSLIDIDSVPTY	DEG_COP1_1	0.5654
p.L118V	ACH-000530	Lung Cancer	CCLE	SSLIDIDSVPTY	DEG_COP1_1	0.5654
p.L118V	DMS-114	lung	COSMIC	SSLIDIDSVPTY	DEG_COP1_1	0.5654
p.D120N	SIDM00153	T-Lymphoblastic Leukemia	GDSC	SSLIDIDSVPTY	DEG_COP1_1	0.6932
p.D120N	ACH-000964	Leukemia	CCLE	SSLIDIDSVPTY	DEG_COP1_1	0.6932
p.L107I	ACH-000681	Lung Cancer	CCLE	SSLIDIDSVPTY	DEG_COP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7LDG7	RAS guanyl-releasing protein 2	DEG_COP1_1	116:127	SSLIDIDSVPTY	COP1	0.5824	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SSLIDIDSVPTY

Degron related mutations and impact score

Drug responses associated with RASGRP2 mutations

All proteins holding degron of SSLIDIDSVPTY